The objectives of this research were to 1) study the basic data of learning innovation to enhance creative young entrepreneurial skills in schools of Kanchanaburi Province, 2) develop the learning innovation to enhance creative young entrepreneurial skills in schools of Kanchanaburi Province, 3) implement the learning innovation to enhance creative young entrepreneurial skills in schools of Kanchanaburi Province, and 4) evaluate the learning innovation to enhance creative young entrepreneurial skills in schools of Kanchanaburi Province. The Research and Development design (R&D) and Appreciation Influence Control technique (AIC) were used for developing the learning innovation to enhance creative young entrepreneurial skills in schools of Kanchanaburi Province. The target group was 59 secondary students in Kanchanaburi Province. The research instruments were interview questions, a questionnaire to confirm the innovation quality, an evaluated form of creative young entrepreneurial skills, and a satisfaction questionnaire for learning innovation. The data were analyzed by frequency, percentage, mean, standard deviation, and content analysis. The finding revealed that: 1) Basic data of learning innovation to enhance creative young entrepreneurial skills in schools found that learning model to enhance entrepreneurial skills comprised professional-based education, skill-based learning, work-based education, work-based learning, project-based learning, and practice-based learning etc.; 2) Learning innovation to enhance creative young entrepreneurial skills in schools, Kanchanaburi Province was composed of input, process and output aspects; 3) Learning innovation to enhance creative young entrepreneurial skills in schools, Kanchanaburi Province trial showed that creative young entrepreneurial skills were at high level in overall and in each aspect; and 4) the evaluation of learning innovation to enhance creative young entrepreneurial skills in schools of Kanchanaburi Province found out the opinion for learning innovation was at high level in overall and each aspect.