Netrin-1 was initially characterized as an axon guidance molecule that is essential for normal embryonic neural development; however, many types of neurons continue to express netrin-1 in the postnatal and adult mammalian brain. Netrin-1 and the netrin receptor DCC are both enriched at synapses. In the adult hippocampus, activity-dependent…

Southern Cross University (SCU) educators and local teachers have developed a five-lesson instructional sequence built around fluke identification as a way of resolving the question: How fast do humpback whales travel up the east coast of Australia?

The shadows cast by moving objects enable human adults and infants to infer the motion trajectories of objects. Nonhuman animals must also be able to discriminate between objects and their shadows and infer the spatial layout of objects from cast shadows. However, the evolutionary and comparative developmental origins of sensitivity to cast…

The activation of cAMP-responsive element-binding protein (CREB)-dependent gene expression is thought to be critical for the formation of different types of long-term memory. To explore the consequences of chronic enhancement of CREB function on spatial memory in mammals, we examined spatial navigation in bitransgenic mice that express in a…

The present study examined spatial learning in goldfish using a new apparatus that was an open-field circular pool with latticed holes. The subjects were motivated to reach the baited hole. We examined gustatory cues, intramaze cues, the possibility that the subject could see the food, etc. In Experiment 1, the position of the baited hole was…

According to the spatial registration hypothesis, the representation of stimulus location is automatically encoded during perception and it can interact with a more abstract linguistic representation. We tested this hypothesis in two experiments, using the semantic judgements of words. In the first experiment, words for animals that either fly or…

Disoriented children could use geometric information in combination with landmark information to reorient themselves in large but not in small experimental spaces. We tested fish in the same task and found that they were able to conjoin geometric and non-geometric (landmark) information to reorient themselves in both the large and the small space…

Hippocampal long-term potentiation (LTP) can be dissociated in early-LTP lasting 4-5 h and late-LTP with a duration of more than 8 h, the latter of which requires protein synthesis and heterosynaptic activity during its induction. Previous studies in vivo have shown that early-LTP in the dentate gyrus can protein synthesis-dependently be…