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Efficacy of Sulforaphane in Treatment of Children with Autism Spectrum Disorder: A Randomized Double-Blind Placebo-Controlled Multi-Center Trial
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Jianjun Ou; Robert C. Smith; Russell H. Tobe; Jingjing Lin; Jen Arriaza; Jed W. Fahey; Ruiting Liu; Ying Zeng; Yanan Liu; Lian Huang; Yidong Shen; Yamin Li; Daomeng Cheng; Brian Cornblatt; John M. Davis; Jingping Zhao; Renrong Wu; Hua Jin – Journal of Autism and Developmental Disorders, 2024
Sulforaphane has been reported to possibly improve core symptoms associated with autism spectrum disorders from mostly small size studies. Here we present results of a larger randomized clinical trial (N = 108) in China. There were no significant changes in caregiver rated scales between sulforaphane and placebo groups. However, clinician rated…
Descriptors: Drug Therapy, Outcomes of Treatment, Autism Spectrum Disorders, Randomized Controlled Trials
Pilot Randomized Controlled Trial of the WHO Caregiver Skills Training in Public Health Services in Italy
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Salomone, Erica; Settanni, Michele; McConachie, Helen; Suma, Katharine; Ferrara, Federica; Foletti, Giulia; Salandin, Arianna; Brown, Felicity L.; Brown, Felicity L.; Pacione, Laura; Shire, Stephanie; Servili, Chiara; Adamson, Lauren B. – Journal of Autism and Developmental Disorders, 2022
Parents of children with ASD (N = 86; mean age 44.8 months; 67 boys) were randomized to either WHO Caregiver Skills Training (CST) delivered in public health settings in Italy or enhanced treatment-as-usual. Primary blinded outcomes were 3-months post-intervention change scores of autism severity and engagement during caregiver-child interaction.…
Descriptors: Caregiver Training, Skill Development, Public Health, Health Services
Learning How to Make Friends for Chinese Adolescents with Autism Spectrum Disorder: A Randomized Controlled Trial of the Hong Kong Chinese Version of the "PEERS"® Intervention
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Shum, Kathy Kar-Man; Cho, Wai Kwan; Lam, Lourdes Mei Oi; Laugeson, Elizabeth A.; Wong, Wai Shan; Law, Louisa S. K. – Journal of Autism and Developmental Disorders, 2019
This study examined the treatment efficacy of "PEERS"® (Program for the Education and Enrichment of Relational Skills) among Chinese adolescents with autism spectrum disorder (ASD) in Hong Kong. The original "PEERS"® manual was translated into Chinese, and cultural adjustments were made according to a survey among 209 local…
Descriptors: Foreign Countries, Autism, Pervasive Developmental Disorders, Asians
Moderating Effects of Parental Characteristics on the Effectiveness of a Theory of Mind Training for Children with Autism: A Randomized Controlled Trial
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de Veld, Danielle M. J.; Howlin, Patricia; Hoddenbach, Elske; Mulder, Fleur; Wolf, Imke; Koot, Hans M.; Lindauer, Ramón; Begeer, Sander – Journal of Autism and Developmental Disorders, 2017
This RCT investigated whether the effect of a Theory of Mind (ToM) intervention for children with ASD was moderated by parental education level and employment, family structure, and parental ASD. Children with autism aged 8-13 years (n = 136) were randomized over a waitlist control or treatment condition. At posttest, children in the treatment…
Descriptors: Autism, Pervasive Developmental Disorders, Theory of Mind, Intervention
The Association between Child and Family Characteristics and the Mental Health and Wellbeing of Caregivers of Children with Autism in Mid-Childhood
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Salomone, Erica; Leadbitter, Kathy; Aldred, Catherine; Barrett, Barbara; Byford, Sarah; Charman, Tony; Howlin, Patricia; Green, Jonathan; Le Couteur, Ann; McConachie, Helen; Parr, Jeremy R.; Pickles, Andrew; Slonims, Vicky; Cole-Fletcher, Rachel; Gammer, Isobel; Maxwell, Jessica; Tobin, Hannah; Vamvakas, George; Cole-Fletcher, Rachle; Gammer, Isobel; Maxwell, Jessica; Tobin, Hannah; Vamvakas, George – Journal of Autism and Developmental Disorders, 2018
We examined predictors of mental health difficulties and wellbeing in caregivers of children with autism in the Pre-school Autism Communication Trial cohort in middle childhood (N = 104). Child's intellectual disability, daily living skills impairment, elevated emotional and behavioural difficulties, high educational level of caregiver and…
Descriptors: Mental Health, Well Being, Autism, Predictor Variables
Cognitive Behaviour Therapy versus a Counselling Intervention for Anxiety in Young People with High-Functioning Autism Spectrum Disorders: A Pilot Randomised Controlled Trial
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Murphy, Suzanne M.; Chowdhury, Uttom; White, Susan W.; Reynolds, Laura; Donald, Louisa; Gahan, Hilary; Iqbal, Zeinab; Kulkarni, Mahesh; Scrivener, Louise; Shaker-Naeeni, Hadi; Press, Dee A. – Journal of Autism and Developmental Disorders, 2017
The use of cognitive-behavioural therapy (CBT) as a treatment for children and adolescents with autism spectrum disorder (ASD) has been explored in a number of trials. Whilst CBT appears superior to no treatment or treatment as usual, few studies have assessed CBT against a control group receiving an alternative therapy. Our randomised controlled…
Descriptors: Autism, Pervasive Developmental Disorders, Cognitive Restructuring, Behavior Modification