Network meta-analysis is a popular method to synthesize the information obtained in a systematic review of studies (e.g., randomized clinical trials) involving subsets of multiple treatments of interest. The dominant method of analysis employs within-study information on treatment contrasts and integrates this over a network of studies. One…

In this response, we first show that Simpson's proposed analysis answers a different and less interesting question than ours. We then justify the choice of prior for our Bayes factors calculations, but we also demonstrate that the substantive conclusions of our article are not substantially affected by varying this choice.

A recent paper uses Bayes factors to argue a large minority of rigorous, large-scale education RCTs are "uninformative." The definition of "uninformative" depends on the authors' hypothesis choices for calculating Bayes factors. These arguably overadjust for effect size inflation and involve a fixed prior distribution,…