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Direct linkRobert C. Lorenz; Mirjam Jenny; Anja Jacobs; Katja Matthias – Research Synthesis Methods, 2024
Conducting high-quality overviews of reviews (OoR) is time-consuming. Because the quality of systematic reviews (SRs) varies, it is necessary to critically appraise SRs when conducting an OoR. A well-established appraisal tool is A Measurement Tool to Assess Systematic Reviews (AMSTAR) 2, which takes about 15-32 min per application. To save time,…
Descriptors: Decision Making, Time Management, Evaluation Methods, Quality Assurance
Caspar J. Van Lissa; Eli-Boaz Clapper; Rebecca Kuiper – Research Synthesis Methods, 2024
The product Bayes factor (PBF) synthesizes evidence for an informative hypothesis across heterogeneous replication studies. It can be used when fixed- or random effects meta-analysis fall short. For example, when effect sizes are incomparable and cannot be pooled, or when studies diverge significantly in the populations, study designs, and…
Descriptors: Hypothesis Testing, Evaluation Methods, Replication (Evaluation), Sample Size
Konstantinos I. Bougioukas; Paschalis Karakasis; Konstantinos Pamporis; Emmanouil Bouras; Anna-Bettina Haidich – Research Synthesis Methods, 2024
Systematic reviews (SRs) have an important role in the healthcare decision-making practice. Assessing the overall confidence in the results of SRs using quality assessment tools, such as "A MeaSurement Tool to Assess Systematic Reviews 2" (AMSTAR 2), is crucial since not all SRs are conducted using the most rigorous methods. In this…
Descriptors: Programming Languages, Research Methodology, Decision Making, Medical Research
Boon, Michele Hilton; Thomson, Hilary – Research Synthesis Methods, 2021
Effect direction (evidence to indicate improvement, deterioration, or no change in an outcome) can be used as a standardized metric which enables the synthesis of diverse effect measures in systematic reviews. The effect direction (ED) plot was developed to support the synthesis and visualization of effect direction data. Methods for the ED plot…
Descriptors: Visualization, Data Analysis, Measurement Techniques, Guidance
Proctor, Tanja; Zimmermann, Samuel; Seide, Svenja; Kieser, Meinhard – Research Synthesis Methods, 2022
During drug development, a biomarker is sometimes identified as separating a patient population into those with more and those with less benefit from evaluated treatments. Consequently, later studies might be targeted, while earlier ones are performed in mixed patient populations. This poses a challenge in evidence synthesis, especially if only…
Descriptors: Comparative Analysis, Meta Analysis, Patients, Medical Research
