Because e-learning encompasses such a wide array of learning methods and tools, its components lend themselves to boundless applications. This study describes one such frontier of e-learning: its use in raising awareness of crucial social issues. Specifically, we describe the development of the first human trafficking awareness e-learning game designed for college students, which was piloted across two U.S. university campuses. College students' usage of and reaction to the research-based e-learning game, which was played on students' smartphones, are explored. Incentives and survey responses are also described for the 227 students who played the game until they received a score of at least 90%. The findings of this study suggest that there is value in using elements of e-learning to raise awareness of crucial social issues, including human trafficking. The majority of participants agreed their knowledge of human trafficking increased, the game was an effective way to create awareness about human trafficking and that they would recommend the game to a peer. Most participants reported that they would prefer learning about human trafficking through a game, instead of a written document. Practical implications, challenges of the game platform, as well as limitations of the study are also described.