Increasing integrity concerns in medical research have prompted the development of tools to detect untrustworthy studies. Existing tools primarily assess published aggregate data (AD), though scrutiny of individual participant data (IPD) is often required to detect trustworthiness issues. Thus, we developed the IPD Integrity Tool for detecting…

Analysis of symmetrically predicted endogenous subgroups (ASPES) is an approach to assessing heterogeneity in an ITT effect from a randomized experiment when an intermediate variable (one that is measured after random assignment and before outcomes) is hypothesized to be related to the ITT effect, but is only measured in one group. For example,…

It is now widely accepted that the standard inferential toolkit used by the scientific research community--null-hypothesis significance testing (NHST)--is not fit for purpose. Yet despite the threat posed to the scientific enterprise, there is no agreement concerning alternative approaches for evidence assessment. This lack of consensus reflects…

This paper represents a philosophical appraisal of Traditional Chinese Medicine (TCM) from the point of view of the philosophy of science. As it is generally the case with other versions of Traditional Medicine, rather than a coherent research program Traditional Chinese Medicine constitutes an array of various techniques and practices coupled…

The debate over what counts as credible evidence often occurs on a methodological level (i.e., about what technical applications of systematic inquiry provide believable, justifiable claims about a program). Less often, it occurs on an epistemological level (i.e., about what ways of knowing are appropriate for making claims about a program). Even…

Across the evidence-based policy and practice (EBPP) community, including education, randomised controlled trials (RCTS) rank as the most "rigorous" evidence for causal conclusions. This paper argues that that is misleading. Only narrow conclusions about study populations can be warranted with the kind of "rigour" that RCTs…

Objective: This study explored the feasibility of stepped care trauma-focused cognitive behavioral therapy (SC-TF-CBT) relative to TF-CBT with children (aged 8--12). Method: Children (N = 33) with post-traumatic stress symptoms (PTSS) were randomly assigned (2:1) to SC-TF-CBT or TF-CBT. SC-TF-CBT consisted of Step 1, parent-led therapist-assisted…