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Direct linkSaluja, Ronak; Cheng, Sierra; delos Santos, Keemo Althea; Chan, Kelvin K. W. – Research Synthesis Methods, 2019
Objective: Various statistical methods have been developed to estimate hazard ratios (HRs) from published Kaplan-Meier (KM) curves for the purpose of performing meta-analyses. The objective of this study was to determine the reliability, accuracy, and precision of four commonly used methods by Guyot, Williamson, Parmar, and Hoyle and Henley.…
Descriptors: Meta Analysis, Reliability, Accuracy, Randomized Controlled Trials
Song, Yue; Sun, Feng; Redline, Susan; Wang, Rui – Research Synthesis Methods, 2020
Meta-analyses of clinical trials typically focus on one outcome at a time. However, treatment decision-making depends on an overall assessment of outcomes balancing benefit in various domains and potential risks. This calls for meta-analysis methods for combined outcomes that encompass information from different domains. When individual patient…
Descriptors: Meta Analysis, Patients, Data, Outcomes of Treatment
Pedder, Hugo; Boucher, Martin; Dias, Sofia; Bennetts, Margherita; Welton, Nicky J. – Research Synthesis Methods, 2020
Time-course model-based network meta-analysis (MBNMA) has been proposed as a framework to combine treatment comparisons from a network of randomized controlled trials reporting outcomes at multiple time-points. This can explain heterogeneity/inconsistency that arises by pooling studies with different follow-up times and allow inclusion of studies…
Descriptors: Simulation, Randomized Controlled Trials, Meta Analysis, Comparative Analysis
Robertson, Clare; Ramsay, Craig; Gurung, Tara; Mowatt, Graham; Pickard, Robert; Sharma, Pawana – Research Synthesis Methods, 2014
We describe our experience of using a modified version of the Cochrane risk of bias (RoB) tool for randomised and non-randomised comparative studies. Objectives: (1) To assess time to complete RoB assessment; (2) To assess inter-rater agreement; and (3) To explore the association between RoB and treatment effect size. Methods: Cochrane risk of…
Descriptors: Risk, Randomized Controlled Trials, Research Design, Comparative Analysis
