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Vousden, George H.; Paulcan, Sloane; Robbins, Trevor W.; Eagle, Dawn M.; Milton, Amy L. – Learning & Memory, 2020
In obsessive-compulsive disorder (OCD), functional behaviors such as checking that a door is locked become dysfunctional, maladaptive, and debilitating. However, it is currently unknown how aversive and appetitive motivations interact to produce functional and dysfunctional behavior in OCD. Here we show a double dissociation in the effects of…
Descriptors: Animal Behavior, Cues, Task Analysis, Punishment
Bourtchouladze, Rusiko; Patterson, Susan L.; Kelly, Michele P.; Kreibich, Arati; Kandel, Eric R.; Abel, Ted – Learning & Memory, 2006
The cAMP/PKA pathway plays a critical role in learning and memory systems in animals ranging from mice to "Drosophila" to "Aplysia." Studies of olfactory learning in "Drosophila" suggest that altered expression of either positive or negative regulators of the cAMP/PKA signaling pathway beyond a certain optimum range may be deleterious. Here we…
Descriptors: Memory, Exhibits, Animals, Associative Learning

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