The main purpose of this study is to determine how computer networks (CNs) affects teaching and learning (T&L) and administrative operations performance at Tanzanian universities. A questionnaire was used as part of a quantitative methodology to gather data for this study. The response rate was 97.95% out of 342 respondents, including students, academic and non-academic staff. Confirmatory factor analysis (CFA) and the PLS-SEM technique in SPSS version 21 were used to analyze the data. Only two (2) of the twelve (12) hypotheses assessed in this study have demonstrated an insignificant effect on university performance in terms of T&L and administrative operations, as indicated by p-values > 0.01. Correlation of CNs and costs/expenses on performance expectancy, as well as the correlation of CNs and conveniences had a statistically insignificant effect on effort expectancy. The results of this study serve as a wake-up call for education stakeholders to revise the current ICT policy to continue adopting CNs infrastructure for enhancing accessibility in T&L and administrative operations. In terms of measures such as cost/expenses, service delivery speed, service quality, and conveniences that were not fully integrated and addressed in earlier similar studies, these variables were evaluated against T&L and administrative performance.