Random encouragement designs evaluate treatments that aim to increase participation in a program or activity. These randomized controlled trials (RCTs) can also assess the mediated effects of participation itself on longer term outcomes using a complier average causal effect (CACE) estimation framework. This article considers power analysis…

Multisite cluster randomized trials (MCRTs), in which, the intermediate-level clusters (e.g., classrooms) are randomly assigned to the treatment or control condition within each site (e.g., school), are among the most commonly used experimental designs across a broad range of disciplines. MCRTs often align with the theory that programs are…

Random encouragement designs are randomized controlled trials (RCTs) that test interventions aimed at increasing participation in a program or activity whose take up is not universal. In these RCTs, instead of randomizing individuals or clusters directly into treatment and control groups to participate in a program or activity, the randomization…

Before embarking on an individual participant data meta-analysis (IPDMA) project, researchers should consider the power of their planned IPDMA conditional on the studies promising their IPD and their characteristics. Such power estimates help inform whether the IPDMA project is worth the time and funding investment, before IPD are collected. Here,…

The meta-analytic-predictive (MAP) approach is a Bayesian method to incorporate historical controls in new trials that aims to increase the statistical power and reduce the required sample size. Here we investigate how to calculate the sample size of the new trial when historical data is available, and the MAP approach is used in the analysis. In…

Cluster randomized control trials often incorporate a longitudinal component where, for example, students are followed over time and student outcomes are measured repeatedly. Besides examining how intervention effects induce changes in outcomes, researchers are sometimes also interested in exploring whether intervention effects on outcomes are…

Cluster randomized trials (CRTs) are commonly used to evaluate educational interventions, particularly their effectiveness. Recently there has been greater emphasis on using these trials to explore cost-effectiveness. However, methods for establishing the power of cluster randomized cost-effectiveness trials (CRCETs) are limited. This study…

Background: Power analysis and sample size planning are key components in designing cluster randomized trials (CRTs), a common study design to test treatment effect by randomizing clusters or groups of individuals. Sample size determination in two-level CRTs requires knowledge of more than one design parameter, such as the effect size and the…

In multisite trials, learning about treatment effect variation across sites is critical for understanding where and for whom a program works. Unadjusted comparisons, however, capture "compositional" differences in the distributions of unit-level features as well as "contextual" differences in site-level features, including…

Background: When RCTs are not feasible and time series data are available, panel data methods can be used to estimate treatment effects on outcomes, by exploiting variation in policies and conditions over time and across locations. A complication with these methods, however, is that treatment timing often varies across the sample, for example, due…

In multisite trials, learning about treatment effect variation across sites is critical for understanding where and for whom a program works. Unadjusted comparisons, however, capture "compositional" differences in the distributions of unit-level features as well as "contextual" differences in site-level features, including…

Cluster randomized trials (CRTs), or studies in which intact groups of individuals are randomly assigned to a condition, are becoming more common in evaluation studies of educational programs. A specific type of CRT in which clusters are randomly assigned to treatment within blocks or sites, known as multisite cluster randomized trials (MSCRTs),…

The What Works Clearinghouse (WWC) is an initiative of the U.S. Department of Education's Institute of Education Sciences (IES), which was established under the Education Sciences Reform Act of 2002. It is an important part of IES's strategy to use rigorous and relevant research, evaluation, and statistics to improve the nation's education system.…

Field experiments in education frequently assign entire groups such as schools to treatment or control conditions. These experiments incorporate sometimes a longitudinal component where for example students are followed over time to assess differences in the average rate of linear change, or rate of acceleration. In this study, we provide methods…

In the "individually randomized group treatment" (IRGT) experimental design, individuals are first randomly assigned to a treatment arm or a control arm, but then within each arm, are grouped together (e.g., within classrooms/schools, through shared case managers, in group therapy sessions, through shared doctors, etc.) to receive…