Developed as a tool to assess working memory capacity in rodents, the odor span task (OST) has significant potential to advance drug discovery in animal models of psychiatric disorders. Prior investigations indicate OST performance is impaired by systemic administration of N-methyl-D-aspartate receptor (NMDA-r) antagonists and is sensitive to…

The present study examined the effects of predatory odor (cat urine) on social novelty preference in Long-Evans rats. Adult male subjects encountered a juvenile conspecific at training, were exposed to either clean cat litter (control) or litter soiled with cat urine (predatory odor), and were tested for social novelty preference. While the…

Compared tendencies of adults and rhesus monkeys to escape adaptively when uncertain. In a visual discrimination task using a threshold paradigm, humans and monkeys escaped trials in which they were uncertain of the stimulus. In a similar task with constant stimuli, some humans escaped adaptively, but one escaped infrequently and non-optimally,…