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Direct linkYuan Tian; Xi Yang; Suhail A. Doi; Luis Furuya-Kanamori; Lifeng Lin; Joey S. W. Kwong; Chang Xu – Research Synthesis Methods, 2024
RobotReviewer is a tool for automatically assessing the risk of bias in randomized controlled trials, but there is limited evidence of its reliability. We evaluated the agreement between RobotReviewer and humans regarding the risk of bias assessment based on 1955 randomized controlled trials. The risk of bias in these trials was assessed via two…
Descriptors: Risk, Randomized Controlled Trials, Classification, Robotics
Qusai Khraisha; Sophie Put; Johanna Kappenberg; Azza Warraitch; Kristin Hadfield – Research Synthesis Methods, 2024
Systematic reviews are vital for guiding practice, research and policy, although they are often slow and labour-intensive. Large language models (LLMs) could speed up and automate systematic reviews, but their performance in such tasks has yet to be comprehensively evaluated against humans, and no study has tested Generative Pre-Trained…
Descriptors: Peer Evaluation, Research Reports, Artificial Intelligence, Computer Software
Saluja, Ronak; Cheng, Sierra; delos Santos, Keemo Althea; Chan, Kelvin K. W. – Research Synthesis Methods, 2019
Objective: Various statistical methods have been developed to estimate hazard ratios (HRs) from published Kaplan-Meier (KM) curves for the purpose of performing meta-analyses. The objective of this study was to determine the reliability, accuracy, and precision of four commonly used methods by Guyot, Williamson, Parmar, and Hoyle and Henley.…
Descriptors: Meta Analysis, Reliability, Accuracy, Randomized Controlled Trials
Pedder, Hugo; Boucher, Martin; Dias, Sofia; Bennetts, Margherita; Welton, Nicky J. – Research Synthesis Methods, 2020
Time-course model-based network meta-analysis (MBNMA) has been proposed as a framework to combine treatment comparisons from a network of randomized controlled trials reporting outcomes at multiple time-points. This can explain heterogeneity/inconsistency that arises by pooling studies with different follow-up times and allow inclusion of studies…
Descriptors: Simulation, Randomized Controlled Trials, Meta Analysis, Comparative Analysis
Armijo-Olivo, Susan; Craig, Rodger; Campbell, Sandy – Research Synthesis Methods, 2020
Background: Evidence from new health technologies is growing, along with demands for evidence to inform policy decisions, creating challenges in completing health technology assessments (HTAs)/systematic reviews (SRs) in a timely manner. Software can decrease the time and burden by automating the process, but evidence validating such software is…
Descriptors: Comparative Analysis, Computer Software, Decision Making, Randomized Controlled Trials
van Valkenhoef, Gert; Dias, Sofia; Ades, A. E.; Welton, Nicky J. – Research Synthesis Methods, 2016
Network meta-analysis enables the simultaneous synthesis of a network of clinical trials comparing any number of treatments. Potential inconsistencies between estimates of relative treatment effects are an important concern, and several methods to detect inconsistency have been proposed. This paper is concerned with the node-splitting approach,…
Descriptors: Networks, Meta Analysis, Automation, Models
Robertson, Clare; Ramsay, Craig; Gurung, Tara; Mowatt, Graham; Pickard, Robert; Sharma, Pawana – Research Synthesis Methods, 2014
We describe our experience of using a modified version of the Cochrane risk of bias (RoB) tool for randomised and non-randomised comparative studies. Objectives: (1) To assess time to complete RoB assessment; (2) To assess inter-rater agreement; and (3) To explore the association between RoB and treatment effect size. Methods: Cochrane risk of…
Descriptors: Risk, Randomized Controlled Trials, Research Design, Comparative Analysis
