A multistep synthesis of a novel arylidene 3­(2"H")-furanone has been designed and optimized for the second-year organic laboratory. The three-step sequence consists of a nucleophilic substitution, intramolecular cyclization, and acid-catalyzed aldol condensation, and can be carried out within two 3 h laboratory periods. The final…

In an upper-division interdisciplinary laboratory experiment, students use Raman spectroscopy to highlight how the overall structure and conformational order of lipid bilayers can be influenced by their individual phospholipid composition. Students prepare a supported lipid bilayer, as a model cell membrane, by spreading liposomes made of various…

In the 1930s, the teaching staff of the University of Chicago devised a clever way to deliver experimental data to their introductory students without meeting them in the laboratory. The university's curriculum included a required Introductory Course in the Physical Sciences. There were probably too many students to allow for a standard…

Using crystal structure data, site directed mutagenesis, and real-time kinetic assays, students designed, expressed, and purified engineered mutants of human insulin-degrading enzyme (IDE). Students designed their own IDE mutants following "in silico" analysis, used inverse PCR to generate mutant plasmid expression constructs, expressed…

Raman scattering is a powerful tool for revealing the vibrations of molecules, but as a nonlinear optical phenomenon, its signals can change via mechanisms like resonance enhancement that have no direct analogue in infrared spectroscopy. In this work, complementary measurements conducted on 4-nitrophenol and its conjugate base allow students to…

Measurement uncertainty is a key topic in the university physics laboratory curriculum. In this study, we investigate students' ability to draw conclusions from measurement data and reasoning about measurement uncertainty in inquiry labs. This investigation centres around a task where students conclude whether measurements from two experiments…

Newton's laws are a ubiquitous topic in introductory physics instruction. One common problem involves asking what will happen if you stick your finger into a cup of water sitting on a scale. A way to solve the problem would be to first recognize that the water exerts a buoyant force upward on the finger, which students can recognize as being the…

Chemists have always designed and deployed cross-disciplinary approaches that interface chemistry with other disciplines to proffer solutions to many human problems. We designed a laboratory experiment that implements chemistry concepts in a biological model to prime undergraduate students to appreciate interdisciplinarity as an approach to…

This communication describes an updated experiment of peptide synthesis, involving determination of the loading capacity of a Fmoc-protected amino functionalized resin using UV-vis spectroscopy and a subsequent synthesis of a dipeptide in order to exemplify the experimental solid-phase synthesis procedure as an alternative technique in organic…

Structure--activity relationships are foundational concepts in biochemistry and drug design. Despite their importance, it can be difficult to create and execute laboratory activities that allow students to directly observe the interactions between small-molecule drugs and their biomolecular targets. Here, we report an activity that investigates…

Pharmaceutical Integrated Experiment (PIE) is a systematic and comprehensive compulsory course for undergraduates majoring in pharmacy and pharmaceutical engineering. This course mainly focuses on integrating the theoretical knowledge of various disciplines into practice, enabling students to master the key processes of drug research and…

Cycloadditions in combination with multicomponent reactions are among the most valuable synthetic tools used by organic chemists to construct cyclic and heterocyclic compounds in a straightforward way. Although cycloadditions, such as the Diels--Alder reaction, are mainly covered in basic and advanced organic courses for undergraduate students,…

Potassium tris(oxalato)ferrate(III) trihydrate is a commonly prepared coordination compound in general or upper-level chemistry laboratories and can be recycled to grow large single crystals that instructors may display when introducing the experiment to classes. Showing the crystal's shape can also be used to briefly introduce students to X-ray…

Although ripple tanks have been used in the past to perform wave simulations for electromagnetic and acoustic phenomena, especially before the advent of computers, they are still often used to demonstrate wave propagation in high school and college physics classrooms. Usually ripple tanks have a rectangular shape. The wave propagating through the…

When thinking about measurement uncertainty in a laboratory experiment that features quantum mechanical effects, it is important to consider both the physical principles of underlying quantum theory (e.g., the uncertainty due to quantum mechanical superposition states) as well as the limitations of the measurement (e.g., the spread in outcomes due…