Local protein synthesis at synapses can provide a rapid supply of proteins to support synaptic changes during consolidation of new memories, but its role in the maintenance or updating of established memories is unknown. Consolidation requires new protein synthesis in the period immediately following learning, whereas established memories are…

Adaptive behavior is characterized by our ability to create, maintain, and update (or switch) rules by which we categorize and respond to stimuli across changing contexts ("cognitive flexibility"). Recent research suggests that people can link the control process of task-switching to contextual cues through associative learning, whereby…

The Remote Associates Test (RAT) is a word association retrieval task that consists of a series of problems, each with three seemingly unrelated prompt words. The subject is asked to produce a single word that is related to all three prompt words. In this paper, we provide support for a theory in which the RAT assesses a person's ability to…

This paper explores a major theoretical framework from psychology, Dual Process Theory (DPT), which has received surprisingly little attention in the computing education literature. DPT postulates the existence of two qualitatively different kinds of cognitive systems, a fast, intuitive "System 1" and a slow, reflective "System…

The updating of a memory is triggered whenever it is reactivated and a mismatch from what is expected (i.e., prediction error) is detected, a process that can be unraveled through the memory's sensitivity to protein synthesis inhibitors (i.e., reconsolidation). As noted in previous studies, in Pavlovian threat/aversive conditioning in adult rats,…

Acetylation of histones changes the efficiency of the transcription processes and thus contributes to the formation of long-term memory (LTM). In our comparative study, we used two inhibitors to characterize the contribution of different histone acetyl transferases (HATs) to appetitive associative learning in the honeybee. For one we applied…

Genetic studies in "Drosophila" have revealed two separable long-term memory pathways defined as anesthesia-resistant memory (ARM) and long-lasting long-term memory (LLTM). ARM is disrupted in "radish" ("rsh") mutants, whereas LLTM requires CREB-dependent protein synthesis. Although the downstream effectors of ARM and LLTM are distinct, pathways…

Contextual stimulus control over instrumental drug-seeking behavior relies on the reconsolidation of context-response-drug associative memories into long-term memory storage following retrieval-induced destabilization. According to previous studies, the basolateral amygdala (BLA) and dorsal hippocampus (DH) regulate cocaine-related memory…