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Direct linkChung, Ain; Dahan, Nessy; Alarcon, Juan Marcos; Fenton, André A. – Learning & Memory, 2017
Nonprotein coding dendritic BC1 RNA regulates translation of mRNAs in neurons. We examined two lines of BC1 knockout mice and report that loss of BC1 RNA exaggerates group I mGluR-stimulated LTD of the Schaffer collateral synapse, with one of the lines showing a much more enhanced DHPG-induced LTD than the other. When the animals were given the…
Descriptors: Memory, Brain Hemisphere Functions, Biochemistry, Animals
Stiver, Mikaela L.; Jacklin, Derek L.; Mitchnick, Krista A.; Vicic, Nevena; Carlin, Justine; O'Hara, Matthew; Winters, Boyer D. – Learning & Memory, 2015
Consolidated memories can become destabilized and open to modification upon retrieval. Destabilization is most reliably prompted when novel information is present during memory reactivation. We hypothesized that the neurotransmitter acetylcholine (ACh) plays an important role in novelty-induced memory destabilization because of its established…
Descriptors: Memory, Animals, Recognition (Psychology), Mnemonics
Sparks, Sarah D. – Education Week, 2012
An explosion in the variety and availability of cognitive-enhancing drugs, from prescriptions like Ritalin to commercial drinks like NeuroFuel, raises concerns for scientists and educators alike--not just over the potential for abuse, but also over what educators and researchers consider, and how they approach, normal achievement. Evidence is…
Descriptors: Drug Therapy, Biochemistry, Stimulants, Improvement
Tharp, Ian J.; Pickering, Alan D. – Brain and Cognition, 2011
Individual differences in psychophysiological function have been shown to influence the balance between flexibility and distractibility during attentional set-shifting [e.g., Dreisbach et al. (2005). Dopamine and cognitive control: The influence of spontaneous eyeblink rate and dopamine gene polymorphisms on perseveration and distractibility.…
Descriptors: Individual Differences, Short Term Memory, Cognitive Ability, Eye Movements
Schulz, Kristina; Korz, Volker – Learning & Memory, 2010
Emotionality as well as cognitive abilities contribute to the acquisition and retrieval of memories as well as to the consolidation of long-term potentiation (LTP), a cellular model of memory formation. However, little is known about the timescale and relative contribution of these processes. Therefore, we tested the effects of weak water maze…
Descriptors: Transfer of Training, Cognitive Processes, Spatial Ability, Water
Bugental, Daphne Blunt; Schwartz, Alex; Lynch, Colleen – Mind, Brain, and Education, 2010
Developmental psychologists have long been concerned with the ways that early adversity influences children's long-term outcomes. In the current study, activity of the hypothalamic-pituitary-adrenal axis of medically at-risk (e.g., preterm) infants was measured as a result of maternal participation in a novel cognitively based home visitation…
Descriptors: Early Intervention, Educational Objectives, Program Effectiveness, Home Visits
Gardiner, Katheleen – Down Syndrome Research and Practice, 2009
Mouse models are a standard tool in the study of many human diseases, providing insights into the normal functions of a gene, how these are altered in disease and how they contribute to a disease process, as well as information on drug action, efficacy and side effects. Our knowledge of human genes, their genetics, functions, interactions and…
Descriptors: Genetics, Symptoms (Individual Disorders), Down Syndrome, Memory
Michaud, Kathy; Forget, Helene; Cohen, Henri – Brain and Cognition, 2009
Cumulative exposure to glucocorticoid hormones (GC) over the lifespan has been associated with cognitive impairment and may contribute to physical and cognitive degeneration in aging. The objective of the present study was to examine whether the pattern of cognitive deficits in patients with Cushing's syndrome (CS), a disorder characterized by…
Descriptors: Control Groups, Patients, Memory, Concept Formation
Naude, H.; Pretorius, E. – Early Child Development and Care, 2003
The effects of asthma medication on the cognitive and psychosocial functioning of primary school children with asthma are investigated. A questionnaire survey was conducted in a primary school in Stellenbosch (South Africa) with a population of six hundred and thirty-five students. Among these students, fifty-nine asthmatic children were…
Descriptors: Foreign Countries, Time Management, Short Term Memory, Diseases
