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Direct linkSerdar Karatoprak; Sadettin Burak Acikel; Abdulbaki Akyildiz; Fatma Coskun; Fatma Hümeyra Yerlikaya – International Journal of Developmental Disabilities, 2024
Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder, the etiology of which has not been clearly determined yet. There is increasing evidence that synaptic and dendritic changes are involved in the etiology of ASD. The aim of this study is to determine whether serum Thrombospondin-1 and Thrombospondin-2 differ between ASD…
Descriptors: Children, Autism Spectrum Disorders, Etiology, Metabolism
Masahiko Inoue; Yoichi Gomi; Soichiro Matsuda – International Journal of Developmental Disabilities, 2024
Introduction: Individuals with intellectual disabilities (ID) are at heightened risk of behavioral problems. Methods: This study investigated differences in the severity of challenging behaviors (CBs) among individuals with IDs at varying life stages. Data were collected from parents' retrospective interviews. Surveys were completed by 47 parents…
Descriptors: Foreign Countries, Intellectual Disability, Adults, Children
Annemieke Hoogstad; Liesbeth Mevissen; Robert Didden – Journal of Developmental and Physical Disabilities, 2024
No research has been conducted on PTSD manifestation in children with severe or moderate intellectual disability (SID; IQ 20-49) and no PTSD measurement instrument was available. This pilot explores the psychometric properties of a new diagnostic instrument to investigate trauma and to classify PTSD in children with SID. The Diagnostic Interview…
Descriptors: Posttraumatic Stress Disorder, Children, Severe Intellectual Disability, Moderate Intellectual Disability
Lloyd, Blair P.; Weaver, Emily S.; Torelli, Jessica N.; Pollack, Marney S.; Fareed, Sunya A.; Maxwell-Horn, Angela C. – American Journal on Intellectual and Developmental Disabilities, 2021
The purpose of the current study was to explore the scientific utility of two behavior analytic assessments (i.e., progressive ratio and demand assessments) for psychotropic medication evaluation. For a sample of 23 children with disabilities who were prescribed medication, we conducted a series of generalizability and optimization studies to…
Descriptors: Disabilities, Children, Drug Therapy, Behavior Problems
Shurtz, Logan; Schwartz, Chloe; DiStefano, Charlotte; McPartland, James C.; Levin, April R.; Dawson, Geraldine; Kleinhans, Natalia M.; Faja, Susan; Webb, Sara J.; Shic, Frederick; Naples, Adam J.; Seow, Helen; Bernier, Raphael A.; Chawarska, Katarzyna; Sugar, Catherine A.; Dziura, James; Senturk, Damla; Santhosh, Megha; Jeste, Shafali S. – Autism: The International Journal of Research and Practice, 2023
Children with autism spectrum disorder are prescribed various medications to address behavior and mood. In clinical trials, individuals taking concomitant psychotropic medications often are excluded to maintain homogeneity and prevent contamination of clinical endpoints. However, this choice may compromise the representativeness of the sample. In…
Descriptors: Autism Spectrum Disorders, Drug Therapy, Incidence, Child Behavior
Latent Class Analysis Identifies Distinctive Behavioral Subtypes in Children with Fragile X Syndrome
Walter E. Kaufmann; Melissa Raspa; Carla M. Bann; Julia M. Gable; Holly K. Harris; Dejan B. Budimirovic; Reymundo Lozano – Journal of Autism and Developmental Disorders, 2024
Fragile X syndrome (FXS) is characterized by variable neurobehavioral abnormalities, which leads to difficulties in developing and evaluating treatments and in determining accurate prognosis. We employed a pediatric cross-sectional sample (1,072 males, 338 females) from FORWARD, a clinic-based natural history study, to identify behavioral subtypes…
Descriptors: Symptoms (Individual Disorders), Children, Genetic Disorders, Intellectual Disability
Mazurek, Micah O.; Lu, Frances; Macklin, Eric A.; Handen, Benjamin L. – Autism: The International Journal of Research and Practice, 2019
The newest edition of the "Diagnostic and Statistical Manual of Mental Disorders" (5th ed., DSM-5) introduced substantial changes to the diagnostic criteria for autism spectrum disorder, including new severity level ratings for social communication and restricted and repetitive behavior domains. The purpose of this study was to evaluate…
Descriptors: Severity (of Disability), Autism, Pervasive Developmental Disorders, Clinical Diagnosis
Scheithauer, Mindy; Call, Nathan A.; Lomas Mevers, Joanna; McCracken, Courtney E.; Scahill, Lawrence – Journal of Autism and Developmental Disorders, 2021
Elopement is a common and dangerous concern in autism spectrum disorder (ASD). There is evidence that behavior analytic treatments can successfully treat elopement, but the research is limited due to small samples and treatment components varying across studies. The current study evaluated the feasibility of studying a manualized intervention for…
Descriptors: Randomized Controlled Trials, Intervention, Behavior Problems, Children
Srivastava, Siddharth; Clark, Bennett; Landy-Schmitt, Colleen; Offermann, Elizabeth A.; Kline, Antonie D.; Wilkinson, Samuel T.; Grados, Marco A. – Journal of Autism and Developmental Disorders, 2021
Cornelia de Lange syndrome (CdLS) is associated with repetitive and self-injurious behaviors (RBs, SIB). Evaluating children with CdLS, this study: (1) characterizes the spectrum of RBs; (2) characterizes the impact and severity of RBs including SIB; (3) describes how age and adaptive functioning relate to RBs including SIB. Fifty children…
Descriptors: Behavior Problems, Self Destructive Behavior, Genetic Disorders, Intellectual Disability
Reliability and Validity of the Pediatric Anxiety Rating Scale Modified for Autism Spectrum Disorder
Maddox, Brenna B.; Lecavalier, Luc; Miller, Judith S.; Pritchett, Jill; Hollway, Jill; White, Susan W.; Gillespie, Scott; Evans, Andrea N.; Schultz, Robert T.; Herrington, John D.; Bearss, Karen; Scahill, Lawrence – Autism: The International Journal of Research and Practice, 2020
Anxiety often co-occurs with autism spectrum disorder, yet there are few valid and reliable instruments for measuring anxiety in youth with autism spectrum disorder. This article describes the modification of the Pediatric Anxiety Rating Scale for youth with autism spectrum disorder and systematic psychometric evaluation in a well-characterized…
Descriptors: Anxiety, Children, Adolescents, Rating Scales
González-Domenech, Pablo José; Díaz Atienza, Francisco; García Pablos, Carlos; Serrano Nieto, Sandra; Herreros Rodríguez, Óscar; Gutiérrez-Rojas, Luis; Martínez-Ortega, José María – Journal of Mental Health Research in Intellectual Disabilities, 2019
Introduction: Diet and dietary interventions have drawn considerable attention in the literature as etiopathogenic factors and therapeutic approaches to Autism Spectrum Disorders (ASD), respectively. The objective of this study was to determine the influence of a gluten-free, casein-free (GFCF) diet on the alterations of behavior in children and…
Descriptors: Dietetics, Behavior Problems, Children, Adolescents
Charlot, Lauren R.; Weigle, Karen L.; Holingue, Calliope B. – Journal of Mental Health Research in Intellectual Disabilities, 2021
Introduction: Individuals with Down syndrome (DS) and IDD have lower psychiatric disorders rates than other individuals with IDD, and more information is needed about possible unique mental health needs of this group. Method: De-identified intake data for individuals with IDD, 101 with DS (mean age 27) and 4,366 without DS (mean age 25) served in…
Descriptors: Down Syndrome, Intellectual Disability, Mental Health, Physical Health
Dean, Olivia M.; Gray, Kylie; Dodd, Seetal; Villagonzalo, Kristi-Ann; Brown, Ellie; Tonge, Bruce; Berk, Michael; Byrne, Linda K. – Journal of Intellectual & Developmental Disability, 2019
Background: Traditional treatment for the behavioural symptoms in autism spectrum disorder (ASD) remains unsatisfactory. There is an urgent need for new, biologically relevant therapies that target both the core and comorbid symptoms that children may experience. This article builds on research previously published by the authors. Method: We…
Descriptors: Autism, Pervasive Developmental Disorders, Intervention, Children
Taylor, Briana J.; Sanders, Kevin B.; Kyle, Marie; Pedersen, Kahsi A.; Veenstra-Vanderweele, Jeremy; Siegel, Matthew – Journal of Autism and Developmental Disorders, 2019
Psychiatric hospitalization of children with autism spectrum disorder (ASD) is common, but there is little comparative information available on different psychiatric hospital treatment models. Children with ASD ages 4-20 were enrolled upon admission to either a specialized (N = 53) or a general child psychiatric unit (N = 27). Caregivers completed…
Descriptors: Psychiatric Hospitals, Patients, Children, Adolescents
McCrae, Christina S.; Chan, Wai Sze; Curtis, Ashley F.; Nair, Neetu; Deroche, Chelsea B.; Munoz, Melissa; Takamatsu, Stephanie; McLean, Deija; Davenport, Mattina; Muckerman, Julie E.; Takahashi, Nicole; McCann, Dillon; McGovney, Kevin; Sahota, Pradeep; Mazurek, Micah O. – Autism: The International Journal of Research and Practice, 2021
Insomnia is common in children with autism. Cognitive behavioral treatment for childhood insomnia may improve sleep and functioning in children with autism and their parents, but delivery involving multiple office visits limits accessibility. This single-arm pilot study tested telehealth delivery of eight-session cognitive behavioral treatment for…
Descriptors: Autism, Pervasive Developmental Disorders, Sleep, Cognitive Restructuring
