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Child Development and Structural Variation in the Human Genome
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Zhang, Ying; Haraksingh, Rajini; Grubert, Fabian; Abyzov, Alexej; Gerstein, Mark; Weissman, Sherman; Urban, Alexander E. – Child Development, 2013
Structural variation of the human genome sequence is the insertion, deletion, or rearrangement of stretches of DNA sequence sized from around 1,000 to millions of base pairs. Over the past few years, structural variation has been shown to be far more common in human genomes than previously thought. Very little is currently known about the effects…
Descriptors: Genetics, Child Development, Molecular Structure, Developmental Disabilities
From Genes to Environment: Using Integrative Genomics to Build a "Systems-Level" Understanding of Autism Spectrum Disorders
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Hu, Valerie W. – Child Development, 2013
Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders that affect an estimated 1 in 110 individuals. Although there is a strong genetic component associated with these disorders, this review focuses on the multifactorial nature of ASD and how different genome-wide (genomic) approaches contribute to our understanding of autism.…
Descriptors: Genetics, Pervasive Developmental Disorders, Autism, Children
The Utility of Chromosomal Microarray Analysis in Developmental and Behavioral Pediatrics
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Beaudet, Arthur L. – Child Development, 2013
Chromosomal microarray analysis (CMA) has emerged as a powerful new tool to identify genomic abnormalities associated with a wide range of developmental disabilities including congenital malformations, cognitive impairment, and behavioral abnormalities. CMA includes array comparative genomic hybridization (CGH) and single nucleotide polymorphism…
Descriptors: Genetics, Genetic Disorders, Developmental Disabilities, Identification
Developmental Outcome of Preterm Infants with Intraventricular Hemorrhage at One and Two Years of Age.
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Sostek, Anita Miller; And Others – Child Development, 1987
This study examined developmental outcome at 1 and 2 years in relation to the presence and severity of neonatal intraventricular hemorrhage. Intraventricular hemorrhage related to Bayley mental and motor scores and neurologic ratings at 1 year but not at 2 years. Significant associations were found between the 1- and 2-year measures but not…
Descriptors: Birth Weight, Child Development, Developmental Disabilities, Followup Studies
Developmental Education for Parents of Delayed Infants: Effects on Parental Motivation and Children's Development.
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Moxley-Haegert, Linda; Serbin, Lisa A. – Child Development, 1983
Comparing developmental education for parents, parent education in child management, and a control situation, this study assessed treatment effectiveness in motivating parents to participate in home programs for developmentally delayed infants. Results indicated the superiority of the developmental program in terms of parent participation and…
Descriptors: Child Development, Comparative Analysis, Developmental Disabilities, Home Programs
Developmental Growth Curves of Preschool Children with Vision Impairments.
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Hatton, Deborah D.; Bailey, Donald B., Jr.; Burchinal, Margaret R.; Ferrell, Kay Alicyn – Child Development, 1997
Used growth curve analysis to describe the development of 186 preschoolers with vision impairments. Found that mental retardation and developmental delay were associated with lower developmental ages and slower growth rates. Visual function of 20/800 or worse was associated with lower developmental ages and slower growth rates in personal-social…
Descriptors: Child Development, Developmental Delays, Developmental Disabilities, Disabilities