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Direct linkHoffman, Janlyn R.; Brandwein, Nathan J.; Nguyen, Peter V. – Learning & Memory, 2019
Beta-adrenergic receptors ([beta]-ARs) prime hippocampal synapses to stabilize long-term potentiation (LTP). This "metaplasticity" can persist for 1-2 h after pharmacologic activation of [beta]-ARs. It requires activation of PKA (cAMP-dependent protein kinase) during [beta]-AR priming. A-kinase anchoring proteins (AKAPs) tether PKA to…
Descriptors: Animals, Science Experiments, Foreign Countries, Stimulation
Cox, Conor D.; Palmer, Linda C.; Pham, Danielle T.; Trieu, Brian H.; Gall, Christine M.; Lynch, Gary – Learning & Memory, 2017
Humans routinely use past experience with complexity to deal with novel, challenging circumstances. This fundamental aspect of real-world behavior has received surprisingly little attention in animal studies, and the underlying brain mechanisms are unknown. The present experiments tested for transfer from past experience in rats and then used…
Descriptors: Animals, Experiential Learning, Brain, Short Term Memory
Download full textGomes da Silva, Sérgio; de Almeida, Alexandre Aparecido; Fernandes, Jansen; Lopim, Glauber Menezes; Cabral, Francisco Romero; Scerni, Débora Amado; de Oliveira-Pinto, Ana Virgínia; Lent, Roberto; Arida, Ricardo Mario – Online Submission, 2016
Clinical evidence has shown that physical exercise during pregnancy may alter brain development and improve cognitive function of offspring. However, the mechanisms through which maternal exercise might promote such effects are not well understood. The present study examined levels of brain-derived neurotrophic factor (BDNF) and absolute cell…
Descriptors: Mothers, Pregnancy, Exercise, Brain Hemisphere Functions
