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Student Difficulties during Structure-Function Problem Solving
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Halmo, Stephanie M.; Sensibaugh, Cheryl A.; Bhatia, Kush S.; Howell, Alexandra; Ferryanto, Ersta P.; Choe, Bryant; Kehoe, Kaitlin; Watson, Morgan; Lemons, Paula P. – Biochemistry and Molecular Biology Education, 2018
Protein structure-function is a key concept in biochemistry. We used the perspective of domain-specific problem-solving to investigate students' solutions to a well-defined protein structure-function problem. We conducted think-aloud interviews with 13 undergraduate students and performed qualitative content analysis to examine the differences in…
Descriptors: Biochemistry, Problem Solving, Science Process Skills, Molecular Structure
Using Molecular Visualization to Explore Protein Structure and Function and Enhance Student Facility with Computational Tools
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Terrell, Cassidy R.; Listenberger, Laura L. – Biochemistry and Molecular Biology Education, 2017
Recognizing that undergraduate students can benefit from analysis of 3D protein structure and function, we have developed a multiweek, inquiry-based molecular visualization project for Biochemistry I students. This project uses a virtual model of cyclooxygenase-1 (COX-1) to guide students through multiple levels of protein structure analysis. The…
Descriptors: Undergraduate Students, College Science, Biochemistry, Science Instruction
Two-Dimensional Nuclear Magnetic Resonance Structure Determination Module for Introductory Biochemistry: Synthesis and Structural Characterization of Lyso-Glycerophospholipids
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Garrett, Teresa A.; Rose, Rebecca L.; Bell, Sidney M. – Biochemistry and Molecular Biology Education, 2013
In this laboratory module, introductory biochemistry students are exposed to two-dimensional [superscript 1]H-nuclear magnetic resonance of glycerophospholipids (GPLs). Working in groups of three, students enzymatically synthesized and purified a variety of 2-acyl lyso GPLs. The structure of the 2-acyl lyso GPL was verified using [superscript…
Descriptors: Diagnostic Tests, Science Laboratories, Biochemistry, College Science
Introductory Bioinformatics Exercises Utilizing Hemoglobin and Chymotrypsin to Reinforce the Protein Sequence-Structure-Function Relationship
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Inlow, Jennifer K.; Miller, Paige; Pittman, Bethany – Biochemistry and Molecular Biology Education, 2007
We describe two bioinformatics exercises intended for use in a computer laboratory setting in an upper-level undergraduate biochemistry course. To introduce students to bioinformatics, the exercises incorporate several commonly used bioinformatics tools, including BLAST, that are freely available online. The exercises build upon the students'…
Descriptors: Biochemistry, Molecular Biology, Molecular Structure, Laboratory Experiments
Student Understanding of pH: "I Don't Know What the Log Actually Is, I Only Know Where the Button Is on My Calculator"
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Watters, Dianne J.; Watters, James J. – Biochemistry and Molecular Biology Education, 2006
In foundation biochemistry and biological chemistry courses, a major problem area that has been identified is students' lack of understanding of pH, acids, bases, and buffers and their inability to apply their knowledge in solving acid/base problems. The aim of this study was to explore students' conceptions of pH and their ability to solve…
Descriptors: Biochemistry, Calculators, Problem Solving, Knowledge Level