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Using Discrete Trial Training to Identify Specific Learning Impairments in Boys with Fragile X Syndrome
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Hall, Scott S.; Hustyi, Kristin M.; Hammond, Jennifer L.; Hirt, Melissa; Reiss, Allan L. – Journal of Autism and Developmental Disorders, 2014
We examined whether "discrete trial training" (DTT) could be used to identify learning impairments in mathematical reasoning in boys with fragile X syndrome (FXS). Boys with FXS, aged 10-23 years, and age and IQ-matched controls, were trained to match fractions to pie-charts and pie-charts to decimals either on a computer or with a…
Descriptors: Learning Disabilities, Mathematical Logic, Males, Genetic Disorders
Evidence of a Distinct Behavioral Phenotype in Young Boys with Fragile X Syndrome and Autism
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Wolff, Jason J.; Bodfish, James W.; Hazlett, Heather C.; Lightbody, Amy A.; Reiss, Allan L.; Piven, Joseph – Journal of the American Academy of Child & Adolescent Psychiatry, 2012
Objective: How does the behavioral expression of autism in fragile X syndrome (FXS + Aut) compare with idiopathic autism (iAut)? Although social impairments and restricted, repetitive behaviors are common to these variants of autism, closer examination of these symptom domains may reveal meaningful similarities and differences. To this end, the…
Descriptors: Genetic Disorders, Mental Retardation, Congenital Impairments, Autism
Psychometric Study of the Aberrant Behavior Checklist in Fragile X Syndrome and Implications for Targeted Treatment
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Sansone, Stephanie M.; Widaman, Keith F.; Hall, Scott S.; Reiss, Allan L.; Lightbody, Amy; Kaufmann, Walter E.; Berry-Kravis, Elizabeth; Lachiewicz, Ave; Brown, Elaine C.; Hessl, David – Journal of Autism and Developmental Disorders, 2012
Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist-Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3-25) with FXS using…
Descriptors: Check Lists, Mental Retardation, Hyperactivity, Factor Structure
Social Behavior and Cortisol Reactivity in Children with Fragile X Syndrome
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Hessl, David; Glaser, Bronwyn; Dyer-Friedman, Jennifer; Reiss, Allan L. – Journal of Child Psychology and Psychiatry, 2006
Objective: To examine the association between limbic-hypothalamic-pituitary-adrenal (L-HPA) axis reactivity and social behavior in children with fragile X syndrome (FXS). Method: Salivary cortisol changes and concurrent anxiety-related behaviors consistent with the behavioral phenotype of FXS were measured in 90 children with the fragile X full…
Descriptors: Stress Variables, Siblings, Nonverbal Communication, Social Behavior
The Neuroanatomy and Neuroendocrinology of Fragile X Syndrome
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Hessl, David; Rivera, Susan M.; Reiss, Allan L. – Mental Retardation and Developmental Disabilities Research Reviews, 2004
Fragile X syndrome (FXS), caused by a single gene mutation on the X chromosome, offers a unique opportunity for investigation of gene-brain-behavior relationships. Recent advances in molecular genetics, human brain imaging, and behavioral studies have started to unravel the complex pathways leading to the cognitive, psychiatric, and physical…
Descriptors: Learning Problems, Genetics, Memory, Brain