Chromosomal 16p11.2 deletion syndrome frequently presents with intellectual disabilities, speech delays, and autism. Here we investigated the Dolmetsch line of 16p11.2 heterozygous (+/-) mice on a range of cognitive tasks with different neuroanatomical substrates. Robust novel object recognition deficits were replicated in two cohorts of 16p11.2…

The "body inversion effect" refers to superior recognition of upright than inverted images of the human body and indicates typical configural processing. Previous research by Reed et al. using static images of the human body shows that people with autism fail to demonstrate this effect. Using a novel task in which adults, adolescents…

Stimulus over-selectivity is a phenomenon displayed by individuals with autism, and has been implicated as a basis for many autistic-spectrum symptoms. In four experiments, non-autistic adult participants were required to learn a simple discrimination using picture cards, and then were tested for the emergence of stimulus over-selectivity, both…