Local protein synthesis at synapses can provide a rapid supply of proteins to support synaptic changes during consolidation of new memories, but its role in the maintenance or updating of established memories is unknown. Consolidation requires new protein synthesis in the period immediately following learning, whereas established memories are…

Adaptive behavior is characterized by our ability to create, maintain, and update (or switch) rules by which we categorize and respond to stimuli across changing contexts ("cognitive flexibility"). Recent research suggests that people can link the control process of task-switching to contextual cues through associative learning, whereby…

Association questions (AQs) are a novel form of multiple-choice questions (MCQs). To answer an AQ, learners must recall the concepts denoted by the given terms, affirm their connections, and then select the term with a denotation that is "less connected" with other concepts. This research hypothesizes that the use of AQ tests for…

The Remote Associates Test (RAT) is a word association retrieval task that consists of a series of problems, each with three seemingly unrelated prompt words. The subject is asked to produce a single word that is related to all three prompt words. In this paper, we provide support for a theory in which the RAT assesses a person's ability to…

This paper explores a major theoretical framework from psychology, Dual Process Theory (DPT), which has received surprisingly little attention in the computing education literature. DPT postulates the existence of two qualitatively different kinds of cognitive systems, a fast, intuitive "System 1" and a slow, reflective "System…

Long-term semantic memory (LTM) is known for affecting recall during working memory (WM) tasks. However, the way LTM intervenes in WM remains unknown. Moreover, the available findings are incongruent concerning how attention modulates the impact of LTM on WM. To examine this issue, the involvement of LTM representations in a complex span task was…

The updating of a memory is triggered whenever it is reactivated and a mismatch from what is expected (i.e., prediction error) is detected, a process that can be unraveled through the memory's sensitivity to protein synthesis inhibitors (i.e., reconsolidation). As noted in previous studies, in Pavlovian threat/aversive conditioning in adult rats,…

Histone deacetylase (HDAC) plays a role in synaptic plasticity and long-term memory formation. We hypothesized that trichostatin-A (TSA), an HDAC inhibitor, would promote long-term odor preference memory and maintain enhanced GluA1 receptor levels that have been hypothesized to support memory. We used an early odor preference learning model in…

Acetylation of histones changes the efficiency of the transcription processes and thus contributes to the formation of long-term memory (LTM). In our comparative study, we used two inhibitors to characterize the contribution of different histone acetyl transferases (HATs) to appetitive associative learning in the honeybee. For one we applied…

What happens to memories as we forget? They might gradually lose fidelity, lose their associations (and thus be retrieved in response to the incorrect cues), or be completely lost. Typical long-term memory studies assess memory as a binary outcome (correct/incorrect), and cannot distinguish these different kinds of forgetting. Here we assess…

Here we examine the role of the exchange protein directly activated by cAMP (Epac) in ß-adrenergic-dependent associative odor preference learning in rat pups. Bulbar Epac agonist (8-pCPT-2-O-Me-cAMP, or 8-pCPT) infusions, paired with odor, initiated preference learning, which was selective for the paired odor. Interestingly, pairing odor with Epac…

This study examines the role of stimulus duration in learning and memory formation of honeybees ("Apis mellifera"). In classical appetitive conditioning honeybees learn the association between an initially neutral, conditioned stimulus (CS) and the occurrence of a meaningful stimulus, the unconditioned stimulus (US). Thereby the CS…

Genetic studies in "Drosophila" have revealed two separable long-term memory pathways defined as anesthesia-resistant memory (ARM) and long-lasting long-term memory (LLTM). ARM is disrupted in "radish" ("rsh") mutants, whereas LLTM requires CREB-dependent protein synthesis. Although the downstream effectors of ARM and LLTM are distinct, pathways…

The nematode "Caenorhabditis elegans" ("C. elegans") adult hermaphrodite has 302 invariant neurons and is suited for cellular and molecular studies on complex behaviors including learning and memory. Here, we have developed protocols for classical conditioning of worms with 1-propanol, as a conditioned stimulus (CS), and hydrochloride (HCl) (pH…

Contextual stimulus control over instrumental drug-seeking behavior relies on the reconsolidation of context-response-drug associative memories into long-term memory storage following retrieval-induced destabilization. According to previous studies, the basolateral amygdala (BLA) and dorsal hippocampus (DH) regulate cocaine-related memory…