This study evaluated whether two people with multiple disabilities and minimal motor behavior would be able to improve their Drag-and-Drop (DnD) performance using their finger/thumb poke ability with a mouse scroll wheel through a Dynamic Drag-and-Drop Assistive Program (DDnDAP). A multiple probe design across participants was used in this study to assess the effects of using DDnDAP in enhancing participants' DnD ability. Both participants: (a) improved their DnD efficiency with the use of DDnDAP and (b) remained highly successful through the maintenance phase. The implications of the findings are discussed. (Contains 5 figures.)