This study provided that people with multiple disabilities can have a collaborative working chance in computer operations through an Enhanced Multiple Cursor Dynamic Pointing Assistive Program (EMCDPAP, a new kind of software that replaces the standard mouse driver, changes a mouse wheel into a thumb/finger poke detector, and manages mouse actions). The study used an ABAB design to evaluate whether four people (two pairs) with multiple disabilities, who have very limited voluntary muscle control and cannot use a standard mouse, would be able to improve their collaborative pointing performance using their finger poke ability with a mouse wheel through EMCDPAP software. The data showed that both pairs of participants improved their collaborative pointing efficiency through the use of the EMCDPAP software during the intervention phase. The practical and developmental implications of the findings are discussed. (Contains 9 figures.)