Background: Forwards citation searching is a valuable method for finding relevant studies in reviews where concepts are not clearly defined. Scopus and Web of Science can both be used for forwards citation searching but there is little evidence comparing the resources for this purpose. Method: 104 source records relevant to a scoping review of…

Background: We undertook a systematic review to evaluate the health benefits of environmental enhancement and conservation activities. We were concerned that a conventional process of study identification, focusing on exhaustive searches of bibliographic databases as the primary search method, would be ineffective, offering limited value. The…

Background: Qualitative research in dementia improves understanding of the experience of people affected by dementia. Searching databases for qualitative studies is problematic. Qualitative-specific search strategies might help with locating studies. Objective: To examine the effectiveness (sensitivity and precision) of 5 qualitative strategies on…

Objective: The objective of this study was to investigate the impact of the peer review of literature search strategies prepared in support of rapid reviews. Methods: A sample of 200 CADTH rapid reviews was selected. For each rapid review meeting the inclusion criteria, the pre-peer-reviewed and corresponding post-peer-reviewed search strategies…

Introduction: The number of systematic reviews of health economic evaluations (SR-HEs) is increasing. We aimed at providing a detailed overview of the characteristics and applied methods in recently published SR-HEs. Methods: We searched MEDLINE (03/2017) for SR-HEs published since 2015 using validated search filters. We included studies that…

Background: Both PubMed and Ovid MEDLINE contain records from the MEDLINE database. However, there are subtle differences in content, functionality, and search syntax between the two. There are many instances in which researchers may wish to search both interfaces, such as when conducting supplementary searching for a systematic review to retrieve…

Objective: Search strategies are essential for the adequate retrieval of studies in a systematic review (SR). Our objective was to identify problems in the design and reporting of search strategies in a sample of new Cochrane SRs first published in The Cochrane Library in 2015. Study design and setting: We took a random sample of 70 new Cochrane…

Meta-analyses of clinical trials targeting rare events face particular challenges when the data lack adequate numbers of events for all treatment arms. Especially when the number of studies is low, standard random-effects meta-analysis methods can lead to serious distortions because of such data sparsity. To overcome this, we suggest the use of…

One of the reasons for the popularity of meta-analysis is the notion that these analyses will possess more power to detect effects than individual studies. This is inevitably the case under a fixed-effect model. However, the inclusion of the between-study variance in the random-effects model, and the need to estimate this parameter, can have…

Using text mining to aid the development of database search strings for topics described by diverse terminology has potential benefits for systematic reviews; however, methods and tools for accomplishing this are poorly covered in the research methods literature. We briefly review the literature on applications of text mining for search term…

Introduction: Registration and publication of trial protocols has become increasingly important and a requirement in some sources of funding and publication. Increased access to protocols yields many potential benefits, but there are issues regarding identification of published protocols. The aim of this investigation is to compare methods of…

Background: It has been reported that information sources searched in systematic reviews (SRs) are insufficiently comprehensive. We analyzed information sources used in SRs, as well as how up-to-date were the searches. Methods: We searched PubMed and the Cochrane Database of Systematic Reviews (CDSR) through Wiley from 2012 to 2016 to find SRs of…

Background: There is an agreement that the methodological quality of randomized trials should be assessed in systematic reviews, but there is a debate on how this should be done. We conducted a construct validation study of the Physiotherapy Evidence Database (PEDro) scale, which is widely used to assess the quality of trials in physical therapy…

Authors and indexers are increasingly including terms for adverse "drug" effects in the titles, abstracts, or indexing of records in MEDLINE and Embase. However, it is not clear if this is the same for studies with "nondrug" adverse effects data. We therefore assessed the feasibility of using adverse effects terms when…

Objective: Identify the most performant automated text classification method (eg, algorithm) for differentiating empirical studies from nonempirical works in order to facilitate systematic mixed studies reviews. Methods: The algorithms were trained and validated with 8050 database records, which had previously been manually categorized as…