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Direct linkQi, Xinyue; Zhou, Shouhao; Wang, Yucai; Peterson, Christine – Research Synthesis Methods, 2022
Meta-analysis allows researchers to combine evidence from multiple studies, making it a powerful tool for synthesizing information on the safety profiles of new medical interventions. There is a critical need to identify subgroups at high risk of experiencing treatment-related toxicities. However, this remains quite challenging from a statistical…
Descriptors: Bayesian Statistics, Identification, Meta Analysis, Data Analysis
Zhao, Hong; Hodges, James S.; Carlin, Bradley P. – Research Synthesis Methods, 2017
Network meta-analysis (NMA) combines direct and indirect evidence comparing more than 2 treatments. Inconsistency arises when these 2 information sources differ. Previous work focuses on inconsistency detection, but little has been done on how to proceed after identifying inconsistency. The key issue is whether inconsistency changes an NMA's…
Descriptors: Meta Analysis, Networks, Hierarchical Linear Modeling, Bayesian Statistics
