Background: Evidence syntheses provide the basis for evidence-based decision making in healthcare. To judge the certainty of findings for the specific decision context evidence syntheses should consider context suitability (ie, generalizability, external validity, applicability or transferability). Our objective was to determine the status quo and…

The aim of the present work was to identify published methodological guidance for rapid reviews (RRs) and to analyze the recommendations with regard to time-saving measures. A literature search was performed in PubMed and EMBASE in November 2020. In addition, a search based on Google Scholar and websites of governmental and non-governmental…

Cochrane reviews are known to be a high-quality source of evidence synthesis supporting health care decisions. In a recently conducted study, we analyzed the trends in epidemiology and reporting of published systematic reviews over the last 20 years. This sample of 1132 systematic reviews included 84 Cochrane reviews. We have learned several…

Contextual factors such as cultural values and traditions impact on implementation processes of healthcare interventions. It is one of the reasons why local stakeholders may decide to role out a programme differently from how it has originally been developed or described in scientific literature. This can result in different but most likely more…

The involvement of non-researcher contributors (eg, stakeholders, patients and the public, decision and policy makers, experts, lay contributors) has taken a variety of forms within evidence syntheses. Realist reviews are a form of evidence synthesis that involves non-researcher contributors yet this practice has received little attention. In…

Background: Forwards citation searching is a valuable method for finding relevant studies in reviews where concepts are not clearly defined. Scopus and Web of Science can both be used for forwards citation searching but there is little evidence comparing the resources for this purpose. Method: 104 source records relevant to a scoping review of…

Evidence-based decision-making is predicated on the ability of users to find and comprehend results from systematic review. Evidence producers have an obligation to support evidence users in this process. The Agency for Healthcare Research and Quality (AHRQ) Evidence-based Practice Center (EPC) program--a producer of rigorous and comprehensive…

Clinical trial data are essential for assessments of the effectiveness of health care interventions. Information about ongoing or completed, but not yet formally published, trials has been more difficult to identify until the development of clinical trials registers and portals. This paper summarises research evidence on identifying sources of…

Background: There is increasing interest from review authors about including non-randomized studies (NRS) in their systematic reviews of health care interventions. This series from the Ottawa Non-Randomized Studies Workshop consists of six papers identifying methodological issues when doing this. Aim: To format the guidance from the preceding…

Background: Selective outcome and analysis reporting (SOR and SAR) occur when only a subset of outcomes measured and analyzed in a study is fully reported, and are an important source of potential bias. Key methodological issues: We describe what is known about the prevalence and effects of SOR and SAR in both randomized controlled trials (RCTs)…