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Direct linkKylie E. Hunter; Mason Aberoumand; Sol Libesman; James X. Sotiropoulos; Jonathan G. Williams; Jannik Aagerup; Rui Wang; Ben W. Mol; Wentao Li; Angie Barba; Nipun Shrestha; Angela C. Webster; Anna Lene Seidler – Research Synthesis Methods, 2024
Increasing concerns about the trustworthiness of research have prompted calls to scrutinise studies' Individual Participant Data (IPD), but guidance on how to do this was lacking. To address this, we developed the IPD Integrity Tool to screen randomised controlled trials (RCTs) for integrity issues. Development of the tool involved a literature…
Descriptors: Integrity, Randomized Controlled Trials, Participant Characteristics, Computer Software
Yao, Minghong; Wang, Yuning; Ren, Yan; Jia, Yulong; Zou, Kang; Li, Ling; Sun, Xin – Research Synthesis Methods, 2023
Rare events meta-analyses of randomized controlled trials (RCTs) are often underpowered because the outcomes are infrequent. Real-world evidence (RWE) from non-randomized studies may provide valuable complementary evidence about the effects of rare events, and there is growing interest in including such evidence in the decision-making process.…
Descriptors: Evidence, Meta Analysis, Randomized Controlled Trials, Decision Making
Armijo-Olivo, Susan; Craig, Rodger; Campbell, Sandy – Research Synthesis Methods, 2020
Background: Evidence from new health technologies is growing, along with demands for evidence to inform policy decisions, creating challenges in completing health technology assessments (HTAs)/systematic reviews (SRs) in a timely manner. Software can decrease the time and burden by automating the process, but evidence validating such software is…
Descriptors: Comparative Analysis, Computer Software, Decision Making, Randomized Controlled Trials
