Over the past thirty years, clinical research has benefited substantially from the adoption of electronic medical record systems. As deployment has increased, so too has the number of researchers seeking to improve the overall analytical environment by way of tools and models. Although much work has been done, there are still many uninvestigated…

Graphs are widely used to model structures and relationships of objects in various scientific and commercial fields. Chemical molecules, proteins, malware system-call dependencies and three-dimensional mechanical parts are all modeled as graphs. In this dissertation, we propose to mine and index those graph data to enable fast and scalable search.…

In today's world, information is increasingly created, processed, transmitted, and stored digitally. While the digital nature of information has brought enormous benefits, it has also created new vulnerabilities and attacks against data. Unlike physical documents, digitally stored information can be rapidly copied, erased, or modified. The…

This dissertation reports the results of an exploratory data analysis investigation of the relationship between the structures used for information organization and access and the associated storage structures within state government websites. Extending an earlier claim that hierarchical directory structures are both the preeminent information…

An unprecedented amount of information encompassing almost every facet of human activities across the world is generated daily in the form of zeros and ones, and that is often the only form in which such information is recorded. A good fraction of this information needs to be preserved for periods of time ranging from a few years to centuries.…

Over the past several decades, millions of digital objects of significant scientific, economic, cultural, and historic value have been published and distributed to libraries and archives on removable media. Providing long-term access to these documents, media files, and software executables is an increasingly complex task because of dependencies…