Most of the world's languages include multiple varieties and dialects. Individual ability to successfully alternate between these varieties can be a socio-cultural and academic necessity for many bilingual speakers, including children in the US who alternate between African American English (AAE) and Mainstream American English (MAE). This…

Reading is a complex task that requires integration of information across brain systems that support sensory, language and cognitive processing. Individuals vary widely in reading ability: some read almost effortlessly, while others struggle to make sense of printed text. Factors at multiple levels from genes and brain through environment…

Early childhood language experiences influence how a child's mind and brain process language and acquire literacy. For children growing up bilingual, their two languages interact in their minds, and these cross-linguistic influences can lead to unique neurocognitive mechanisms for language and reading compared to monolinguals. In this…

This project used Event-Related Potentials (ERPs) to explore neurophysiological brain responses to prepositional phrases involving concrete and abstract reference nouns (e.g., "plate" and "moment," respectively) after the presentation of objects with varying spatial features. Prepositional phrases were headed by "in"…

The field of research in bilingualism and second language (L2) acquisition has yielded overwhelming evidence that acquiring a second language later in life will result in less accurate production and perception of consonants and vowels in the second language. These effects, in part, are a result of interference from the already formed phonetic…

This dissertation contains several projects, each addressing different questions with different techniques. In chapter 1, I argue that they are unified thematically by their goal of "scaling up psycholinguistics"; they are all aimed at analyzing large data-sets using tools that reveal patterns to propose and test mechanism-neutral hypotheses about…

Intercellular signaling is vital to communication within neuronal circuits. The suprachiasmatic nucleus (SCN), the master circadian clock of mammals, contains a dense collection of neurons that align their intrinsic rhythmicity with environmental stimulus and physiological state. While peptide physiology has been demonstrated as a contributor to…

It has long been appreciated that adequate nutrition is required for proper immune function and it is now recognized that dietary components contribute to modulation of immune cells, subsequently impacting the whole body's response during an immune challenge. Macrophage activation plays a critical role in the immune system and directs the…

The scope, breadth, and volume of data characterizing our current understanding of how the brain functions is growing at an increasingly rapid pace. What is more, theories are becoming increasing complex and nuanced, integrating knowledge from multiple previously independent sources of scientific inquiry. The research described within this…

Short term synaptic plasticity is a phenomenon which is commonly found in the central nervous system. It could contribute to functions of signal processing namely, temporal integration and coincidence detection by modulating the input synaptic strength. This dissertation has two parts. First, we study the effects of short term synaptic plasticity…

Excessive production of pro-inflammatory mediators by activated brain microglia plays an important role in abnormal neuronal function and cognitive deficits. Studies have shown that the intake of flavonoids is inversely related to cognitive decline and dementia in people 65 years of age or older. Luteolin, a flavonoid found in high concentrations…