This module was initially developed for a course in applications of mathematics in biology. The objective of this lesson is to investigate how the allele and genotypic frequencies associated with a particular gene might evolve over successive generations. The lesson will discuss how the Hardy-Weinberg model provides a basis for comparison when…

The material in this module introduces students to some of the mathematical tools used to examine molecular evolution. This topic is standard fare in many mathematical biology or bioinformatics classes, but could also be suitable for classes in linear algebra or probability. While coursework in matrix algebra, Markov processes, Monte Carlo…

This article describes the sequence alignment problem in bioinformatics. Through examples, we formulate sequence alignment as an optimization problem and show how to compute the optimal alignment with dynamic programming. The examples and sample exercises have been used by the author in a specialized course in bioinformatics, but could be adapted…