This module was initially developed for a course in applications of mathematics in biology. The objective of this lesson is to investigate how the allele and genotypic frequencies associated with a particular gene might evolve over successive generations. The lesson will discuss how the Hardy-Weinberg model provides a basis for comparison when…

This material has been used twice as an out-of-class project in a mathematical modeling class, the first elective course for mathematics majors. The only prerequisites for this course were differential and integral calculus, but all students had been exposed to differential equations, and the project was assigned during discussions about solving…

As part of an integrative learning experience at the end of a sophomore Calculus II course at the United States Military Academy, this project served as a multidisciplinary problem-solving exercise that explored the connections among mathematics, biology, and other fields of study. During a seven-lesson block of instruction, this module was…

This article describes the sequence alignment problem in bioinformatics. Through examples, we formulate sequence alignment as an optimization problem and show how to compute the optimal alignment with dynamic programming. The examples and sample exercises have been used by the author in a specialized course in bioinformatics, but could be adapted…

At United States Military Academy, a unit on biological modeling applications forms the culminating component of the first semester core mathematics course for freshmen. The course emphasizes the use of problem-solving strategies and modeling to solve complex and ill-defined problems. Topic areas include functions and their shapes, data fitting,…