This paper presents an example of how usability design strategies for children can be designed into educational material using CD-ROM based multimedia application for assisting parents and teachers to develop children's learning and knowledge in decreasing as well as motivate children aged 7-9 years old to reduce their anxious feelings towards dental treatment. In this paper, the authors provide usability design strategies for children in designing the information interfaces and presentation of a PMLE (persuasive multimedia learning environment). PMLE is designed based on the six design categories of guidelines for children which have been applied to this study: general interaction, text, multimedia, navigation and search, graphical user interface and content. The results on presenting this PMLE to 240 primary school children selected at random show how the authors were able to decrease children's dental anxiety and motivate the children to get ready for dental visit. (Contains 6 figures and 4 tables.)