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Marchal, Paul; Villar, Maria Eugenia; Geng, Haiyang; Arrufat, Patrick; Combe, Maud; Viola, Haydée; Massou, Isabelle; Giurfa, Martin – Learning & Memory, 2019
Honeybees are a standard model for the study of appetitive learning and memory. Yet, fewer attempts have been performed to characterize aversive learning and memory in this insect and uncover its molecular underpinnings. Here, we took advantage of the positive phototactic behavior of bees kept away from the hive in a dark environment and…
Descriptors: Inhibition, Learning Processes, Memory, Molecular Structure
Leake, Jessica; Zinn, Raphael; Corbit, Laura; Vissel, Bryce – Learning & Memory, 2017
Rodents require a minimal time period to explore a context prior to footshock to display plateau-level context fear at test. To investigate whether this rapid fear plateau reflects complete memory formation within that short time-frame, we used the immediate-early gene product Arc as an indicator of hippocampal context memory formation-related…
Descriptors: Fear, Memory, Animals, Context Effect
Klingmüller, Angela; Caplan, Jeremy B.; Sommer, Tobias – Learning & Memory, 2017
It would be profoundly important if reconsolidation research in animals and other memory domains generalized to human episodic memory. A 3-d-list-discrimination procedure, based on free recall of objects, with a contextual reminder cue (the testing room), has been thought to demonstrate reconsolidation of human episodic memory (as noted in a…
Descriptors: Memory, Recall (Psychology), Interference (Learning), Cognitive Processes
Liu, Rong-Yu; Neveu, Curtis; Smolen, Paul; Cleary, Leonard J.; Byrne, John H. – Learning & Memory, 2017
Developing treatment strategies to enhance memory is an important goal of neuroscience research. Activation of multiple biochemical signaling cascades, such as the protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) pathways, is necessary to induce long-term synaptic facilitation (LTF), a correlate of long-term memory (LTM).…
Descriptors: Drug Therapy, Biochemistry, Pharmacology, Intervention
Wang, Gong-Wu; Liu, Jian; Wang, Xiao-Qin – Learning & Memory, 2017
The ventral hippocampus (VH) and the basolateral amygdala (BLA) are both crucial in inhibitory avoidance (IA) memory. However, the exact role of the VH-BLA circuit in IA memory consolidation is unclear. This study investigated the effect of post-training reversible disconnection of the VH-BLA circuit in IA memory consolidation. Male Wistar rats…
Descriptors: Animals, Memory, Brain Hemisphere Functions, Inhibition
Vogel, Susanne; Kluen, Lisa Marieke; Fernández, Guillén; Schwabe, Lars – Learning & Memory, 2018
Prior knowledge, represented as a mental schema, has critical impact on how we organize, interpret, and process incoming information. Recent findings indicate that the use of an existing schema is coordinated by the medial prefrontal cortex (mPFC), communicating with parietal areas. The hippocampus, however, is crucial for encoding…
Descriptors: Stress Variables, Brain Hemisphere Functions, Cognitive Processes, Schemata (Cognition)
Aten, Sydney; Hansen, Katelin F.; Snider, Kaitlin; Wheaton, Kelin; Kalidindi, Anisha; Garcia, Ashley; Alzate-Correa, Diego; Hoyt, Kari R.; Obrietan, Karl – Learning & Memory, 2018
The microRNA miR-132 serves as a key regulator of a wide range of plasticity-associated processes in the central nervous system. Interestingly, miR-132 expression has also been shown to be under the control of the circadian timing system. This finding, coupled with work showing that miR-132 is expressed in the hippocampus, where it influences…
Descriptors: Neurology, Brain Hemisphere Functions, Memory, Animals
Briskin-Luchinsky, Valeria; Levy, Roi; Halfon, Maayan; Susswein, Abraham J. – Learning & Memory, 2018
Training "Aplysia" with inedible food for a period that is too brief to produce long-term memory becomes effective in producing memory when training is paired with a nitric oxide (NO) donor. Lip stimulation for the same period of time paired with an NO donor is ineffective. Using qPCR, we examined molecular correlates of brief training…
Descriptors: Animals, Training, Food, Long Term Memory
Snow, Wanda M.; Cadonic, Chris; Cortes-Perez, Claudia; Chowdhury, Subir K. Roy; Djordjevic, Jelena; Thomson, Ella; Bernstein, Michael J.; Suh, Miyoung; Fernyhough, Paul; Albensi, Benedict C. – Learning & Memory, 2018
The brain has a high demand for energy, of which creatine (Cr) is an important regulator. Studies document neurocognitive benefits of oral Cr in mammals, yet little is known regarding their physiological basis. This study investigated the effects of Cr supplementation (3%, w/w) on hippocampal function in male C57BL/6 mice, including spatial…
Descriptors: Energy, Brain Hemisphere Functions, Animals, Spatial Ability
Quintana, Gonzalo R.; Guizar, Andrés; Rassi, Sarah; Pfaus, James G. – Learning & Memory, 2018
We have shown previously that male rats develop a conditioned ejaculatory preference (CEP) for females scented with a neutral odor like almond or lemon that is paired with the male's post-ejaculatory reward state during their first and subsequent early sexual experiences. However, preexposing males to the neutral odor alone prior to its pairing…
Descriptors: Animals, Males, Sexuality, Olfactory Perception
Peters, Jamie; Scofield, Michael D.; Reichel, Carmela M. – Learning & Memory, 2018
Prolonged use of methamphetamine (meth) has been associated with episodic memory deficits in humans, and preclinical rat models of meth self-administration indicate the memory deficits are a consequence of meth use. Others have suggested that the meth-induced memory deficits may promote a cyclical pattern of drug use, abstinence, and relapse,…
Descriptors: Drug Abuse, Memory, Brain Hemisphere Functions, Animals
Javadi, Amir-Homayoun; Tolat, Anisha; Spiers, Hugo J. – Learning & Memory, 2015
Sleep is thought to play an important role in memory consolidation. Here we tested whether sleep alters the subjective value associated with objects located in spatial clusters that were navigated to in a large-scale virtual town. We found that sleep enhances a generalization of the value of high-value objects to the value of locally clustered…
Descriptors: Sleep, Memory, Simulated Environment, Generalization
Bowers, Mallory E.; Xia, Bing; Carreiro, Samantha; Ressler, Kerry J. – Learning & Memory, 2015
Evidence indicates that broad, nonspecific histone deacetylase (HDAC) inhibition enhances learning and memory, however, the contribution of the various HDACs to specific forms of learning is incompletely understood. Here, we show that the Class I HDAC inhibitor, RGFP963, enhances consolidation of cued fear extinction. However, RGFP966, a strong…
Descriptors: Inhibition, Memory, Cues, Cognitive Processes
Yu, Yang-Jung; Huang, Chien-Hsuan; Chang, Chih-Hua; Gean, Po-Wu – Learning & Memory, 2016
Destabilization refers to a memory that becomes unstable when reactivated and is susceptible to disruption by amnestic agents. Here we delineated the cellular mechanism underlying the destabilization of drug memory. Mice were conditioned with methamphetamine (MeAM) for 3 d, and drug memory was assessed with a conditioned place preference (CPP)…
Descriptors: Stimulants, Memory, Animals, Brain
Ciernia, Annie Vogel; Kramár, Enikö A.; Matheos, Dina P.; Havekes, Robbert; Hemstedt, Thekla J.; Magnan, Christophe N.; Sakata, Keith; Tran, Ashley; Azzawi, Soraya; Lopez, Alberto; Dang, Richard; Wang, Weisheng; Trieu, Brian; Tong, Joyce; Barrett, Ruth M.; Post, Rebecca J.; Baldi, Pierre; Abel, Ted; Lynch, Gary; Wood, Marcelo A. – Learning & Memory, 2017
Recent human exome-sequencing studies have implicated polymorphic Brg1-associated factor (BAF) complexes (mammalian SWI/SNF chromatin remodeling complexes) in several intellectual disabilities and cognitive disorders, including autism. However, it remains unclear how mutations in BAF complexes result in impaired cognitive function. Post-mitotic…
Descriptors: Intellectual Disability, Autism, Genetics, Neurological Impairments

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