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Direct linkJohnson, Sarah A.; Sacks, Patricia K.; Turner, Sean M.; Gaynor, Leslie S.; Ormerod, Brandi K.; Maurer, Andrew P.; Bizon, Jennifer L.; Burke, Sara N. – Learning & Memory, 2016
Hippocampal-dependent episodic memory and stimulus discrimination abilities are both compromised in the elderly. The reduced capacity to discriminate between similar stimuli likely contributes to multiple aspects of age-related cognitive impairment; however, the association of these behaviors within individuals has never been examined in an animal…
Descriptors: Brain Hemisphere Functions, Animals, Models, Tests
Knutson, Ashley R.; Hopkins, Ramona O.; Squire, Larry R. – Learning & Memory, 2013
We tested proposals that medial temporal lobe (MTL) structures support not just memory but certain kinds of visual perception as well. Patients with hippocampal lesions or larger MTL lesions attempted to identify the unique object among twin pairs of objects that had a high degree of feature overlap. Patients were markedly impaired under the more…
Descriptors: Visual Discrimination, Neurological Impairments, Patients, Memory
Brown, Richard E.; Wong, Aimee A. – Learning & Memory, 2007
We calculated visual ability in 13 strains of mice (129SI/Sv1mJ, A/J, AKR/J, BALB/cByJ, C3H/HeJ, C57BL/6J, CAST/EiJ, DBA/2J, FVB/NJ, MOLF/EiJ, SJL/J, SM/J, and SPRET/EiJ) on visual detection, pattern discrimination, and visual acuity and tested these and other mice of the same strains in a behavioral test battery that evaluated visuo-spatial…
Descriptors: Memory, Visual Acuity, Memorization, Animals
