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Direct linkFrick, Karyn M.; Kim, Jaekyoon; Tuscher, Jennifer J.; Fortress, Ashley M. – Learning & Memory, 2015
Ample evidence has demonstrated that sex steroid hormones, such as the potent estrogen 17ß-estradiol (E[subscript 2]), affect hippocampal morphology, plasticity, and memory in male and female rodents. Yet relatively few investigators who work with male subjects consider the effects of these hormones on learning and memory. This review describes…
Descriptors: Metabolism, Brain Hemisphere Functions, Gender Differences, Animals
Keeley, Robin J.; Wartman, Brianne C.; Hausler, Alexander N.; Holahan, Matthew R. – Learning & Memory, 2010
Research has demonstrated that Long-Evans rats (LER) display superior mnemonic function over Wistar rats (WR). These differences are correlated with endogenous and input-dependent properties of the hippocampus. The present work sought to determine if juvenile pretraining might enhance hippocampal structural markers and if this would be associated…
Descriptors: Gender Differences, Adolescents, Brain Hemisphere Functions, Spatial Ability
Wiltgen, Brian J.; Sanders, Matthew J.; Ferguson, Carolyn; Homanics, Gregg E.; Fanselow, Michael S. – Learning & Memory, 2005
The [delta] subunit of the GABA[subscript [Alpha]] receptor (GABA[subscript [Alpha]]R) is highly expressed in the dentate gyrus of the hippocampus. Genetic deletion of this subunit reduces synaptic and extrasynaptic inhibition and decreases sensitivity to neurosteroids. This paper examines the effect of these changes on hippocampus-dependent trace…
Descriptors: Conditioning, Inhibition, Fear, Animals
