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Direct linkHaque, Rafi U.; Manzanares, Cecelia M.; Brown, Lavonda N.; Pongos, Alvince L.; Lah, James J.; Clifford, Gari D.; Levey, Allan I. – Learning & Memory, 2019
The entorhinal-hippocampal circuit is one of the earliest sites of cortical pathology in Alzheimer's disease (AD). Visuospatial memory paradigms that are mediated by the entorhinal-hippocampal circuit may offer a means to detect memory impairment during the early stages of AD. In this study, we developed a 4-min visuospatial memory paradigm called…
Descriptors: Alzheimers Disease, Memory, Visual Perception, Spatial Ability
Tong, Michelle T.; Kim, Tae-Young P.; Cleland, Thomas A. – Learning & Memory, 2018
Long-term fear memory formation in the hippocampus and neocortex depends upon brain-derived neurotrophic factor (BDNF) signaling after acquisition. Incremental, appetitive odor discrimination learning is thought to depend substantially on the differentiation of adult-born neurons within the olfactory bulb (OB)--a process that is closely associated…
Descriptors: Memory, Olfactory Perception, Role, Animals
