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Direct linkSossin, Wayne S. – Learning & Memory, 2007
Protein kinase Cs (PKCs) are implicated in many forms of synaptic plasticity. However, the specific isoform(s) of PKC that underlie(s) these events are often not known. We have used "Aplysia" as a model system in order to investigate the isoform specificity of PKC actions due to the presence of fewer isoforms and a large number of documented…
Descriptors: Biochemistry, Molecular Biology, Physiology, Structural Analysis (Science)
Boehm, Jannic; Ehrlich, Ingrid; Hsieh, Helen; Malinow, Roberto – Learning & Memory, 2006
The regulated trafficking of GluR1 contributes significantly to synaptic plasticity, but studies addressing the function of the GluR1 C-terminal PDZ-ligand domain in this process have produced conflicting results. Here, we resolve this conflict by showing that apparently similar C-terminal mutations of the GluR1 PDZ-ligand domain result in…
Descriptors: Cytology, Biological Influences, Physiology, Convergent Thinking
