The present meta-analysis examines the relationships between the Five Factor Model (FFM) of personality and negative and positive forms of work-nonwork spillover (e.g., work-family conflict and facilitation). Results, based on aggregated correlations drawn from 66 studies and 72 independent samples (Total N = 28,127), reveal that the FFM is predictive of work-nonwork spillover. More specifically, meta-analytic structural equation modeling indicated that extraversion ([beta] = -0.08), agreeableness ([beta] = -0.06), conscientiousness ([beta] = -0.13), and neuroticism ([beta] = 0.29) are related to negative work-nonwork spillover, while extraversion ([beta] = 0.27), agreeableness ([beta] = 0.11), conscientiousness ([beta] = 0.12), and openness to experience ([beta] = 0.20) are related to positive work-nonwork spillover. FFM personality variables were equally predictive of both directions of spillover (i.e., work-to-nonwork and nonwork-to-work). Collectively these results suggest a moderate amount of variance in negative (R[superscript 2] = 0.15) and positive (R[superscript 2] = 0.18) work-nonwork spillover is accounted for by personality. (Contains 3 tables and 1 figure.)