Background: People with intellectual and developmental disabilities (IDD) from low income diverse communities are experiencing the health impacts of the COVID-19 pandemic most acutely. Method: To better understand the impacts of the pandemic on the wellbeing of adults with IDD from an urban US region and how they are managing the associated disruptions, in-depth qualitative interviews were conducted with 14 participants. A modified grounded theory approach was used to analyze data. Results: Participants experienced stress in response to pandemic media reports and attempted to cope by sanitizing and wearing masks. These did little to reduce stress and may have added to frustration with non-compliers. Social distancing limited access to family, leading to isolation. Participants who engaged in spiritual practices, physical fitness and creative activities were more successful in coping. Conclusions: People with IDD may benefit from mindfulness practices or developing creative hobbies to be better equipped to cope.