Optimal design of multisite randomized trials leverages sampling costs to optimize sampling ratios and ultimately identify more efficient and powerful designs. Past implementations of the optimal design framework have assumed that costs of sampling units are equal across treatment conditions. In this study, we developed a more flexible optimal…

Sample size determination in multilevel randomized trials (MRTs) and multilevel regression discontinuity designs (MRDDs) can be complicated due to multilevel structure, monetary restrictions, differing marginal costs per treatment and control units, and range restrictions in sample size at one or more levels. These issues have sparked a set of…

When well-implemented, mediation analyses play a critical role in probing theories of action because their results help lay the ground work for the critical development of a treatment and the iterative advancement of theories that are foundational to a discipline. Despite strong interest in designs that incorporate mediation, few studies have…