Reading monitoring is poorly explored, but it may have an impact on well-documented reading comprehension difficulties in autism. This study explores reading monitoring through the impact of instructions and different error types on reading behavior. Individuals with autism and matched controls read correct sentences and sentences containing orthographic and semantic errors. Prior to the task, participants were given instructions either to focus on semantic or orthographic errors. Analysis of eye-movements showed that the group with autism, differently from controls, were less influenced by the error's type in the regression-out to-error measure, showing less change in eye-movements behavior between error types. Individuals with autism might find it more difficult to adapt their reading strategies to various reading materials and task demands.