The addition of 'clinically significant impairment' (American Psychiatric Association, Diagnostic and statistical manual of mental disorders, Author, 2013) to the diagnostic criteria for autism in DSM-5 attempts to establish a threshold for the condition. However, the increased prominence of the neurodiversity paradigm and social model of…

The commentary on the consensus statement (EC 232 063) of a panel of experts on treatment of destructive and self-injurious behaviors in persons with developmental disabilities is generally supportive but notes the absence of certain prominent individuals on the panel and questions the panel's recommendation concerning pharmacological treatment.…

Five siblings of autistic children relate some of their own experiences and provide insight on how this handicap manifests itself throughout the family's environment. A psychiatrist experienced with autistic children and their families comments on the siblings' stories. (SBH)

The sources of variability residing in the environment of individuals with autism and the implications for research studies are explored. Recommendations are provided for future research including research focusing on young children, on the methods needed to produce desirable outcomes, on relationships between behaviors, and on specific teaching…

This commentary uses self-injurious behavior to illustrate the approach of the functional analysis of behavior as a guide to rational treatment strategies for individuals with autism, and to show that the characteristics of the clinical presentations can provide clues for underlying mechanisms that can be used for research and treatment. (Contains…

This commentary discusses the wide acceptance of and the expenditure of limited resources on unproven behavioral therapies for individuals with autism. Considerations that need to be reviewed before adopting a behavioral treatment are outlined, including the need to establish whether direct effects can be attributed to a treatment. (Contains 11…

This article comments on results of a study (EC 629 869) on the reliability of the Modified Checklist for Autism in Toddlers (M-CHAT), a early detection screening test. It discusses concerns relating to clinic vs. population samples, data analysis, use of a parent questionnaire only to identify autism, and the age of screening. (Contains…

This article responds to comments (EC 629 869-70) on a study on the reliability of the Modified Checklist for Autism in Toddlers (M-CHAT), a early detection screening test. It addresses concerns relating to clinic vs. population samples, data analysis, use of a parent questionnaire only to identify autism, and the age of screening. (Contains 6…

The consensus statement of a panel of experts on treatment of destructive and self-injurious behaviors in persons with developmental disabilities addresses such areas as approaches used to manage these behaviors; evidence for the effectiveness of various approaches; the risks and benefits of the various approaches; recommendations; and needed…

The possibility of differential sex proportions as a confounding factor in the Lovaas (1987) study is raised. It is argued that the chi-square analysis was inadequate and that the appropriate comparison should be made between the experimental and the control group using population data to estimate expected cell frequencies. (Author/CR)

This commentary discusses study results that indicate the nonselective serotonin reuptake inhibitor (SRI) clomipramine is more efficacious than the relatively selective norepinephrine reuptake inhibitor desipramine and placebo in treating repetitive or ritualized behaviors in children with autism. The need for concurrent genetic and biochemical…

This article reviews the psychopharmacological treatment of aggression, mood disturbances, and self-injurious behavior in persons with autistic disorder. It highlights the use of dopaminergic drugs, serotonergic drugs, opioidergic drugs, adrenergic drugs, thymoleptic drugs, and glutamatergic drugs for their potential utility in treating…