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Peer reviewed
Direct linkJianjun Ou; Robert C. Smith; Russell H. Tobe; Jingjing Lin; Jen Arriaza; Jed W. Fahey; Ruiting Liu; Ying Zeng; Yanan Liu; Lian Huang; Yidong Shen; Yamin Li; Daomeng Cheng; Brian Cornblatt; John M. Davis; Jingping Zhao; Renrong Wu; Hua Jin – Journal of Autism and Developmental Disorders, 2024
Sulforaphane has been reported to possibly improve core symptoms associated with autism spectrum disorders from mostly small size studies. Here we present results of a larger randomized clinical trial (N = 108) in China. There were no significant changes in caregiver rated scales between sulforaphane and placebo groups. However, clinician rated…
Descriptors: Drug Therapy, Outcomes of Treatment, Autism Spectrum Disorders, Randomized Controlled Trials
Katherine Pye; Hannah Jackson; Teresa Iacono; Alan Shiell – Journal of Autism and Developmental Disorders, 2024
Many autistic children access some form of early intervention, but little is known about the value for money of different programs. We completed a scoping review of full economic evaluations of early interventions for autistic children and/or their families. We identified nine studies and reviewed their methods and quality. Most studies involved…
Descriptors: Economics, Early Intervention, Autism Spectrum Disorders, Children
Yang, Yoon Jung; Chung, Kyong-Mee – Journal of Autism and Developmental Disorders, 2023
This study developed and tested the effectiveness of an app-based cognitive behavioral therapy (CBT) program in alleviating anxiety among adolescents and adults with autism without co-occurring intellectual disability. Thirty participants from 15 to 35 years old were randomly assigned to either the intervention or waitlist control group, and self-…
Descriptors: Pilot Projects, Randomized Controlled Trials, Handheld Devices, Behavior Modification
de Veld, Danielle M. J.; Scheeren, Anke M.; Howlin, Patricia; Hoddenbach, Elske; Mulder, Fleur; Wolf, Imke; Begeer, Sander – Journal of Autism and Developmental Disorders, 2021
This RCT investigated whether participants' sibling configuration moderated the effect of a Theory of Mind (ToM) intervention for children with autism. Children with autism aged 8-13 years (n = 141) were randomized over a waitlist control or treatment condition. Both having more siblings, as well as having an older sibling were related to better…
Descriptors: Siblings, Birth Order, Theory of Mind, Training
Weitlauf, Amy S.; Broderick, Neill; Alacia Stainbrook, J.; Slaughter, James C.; Taylor, Julie Lounds; Herrington, Catherine G.; Nicholson, Amy G.; Santulli, Madeline; Dorris, Kristin; Garrett, LaTamara Jackson; Hopton, Michelle; Kinsman, Amy; Morton, Mary; Vogel, Ashley; Dykens, Elisabeth M.; Pablo Juárez, A.; Warren, Zachary E. – Journal of Autism and Developmental Disorders, 2022
This randomized controlled trial (NCT03889821) examined Mindfulness Based Stress Reduction (MBSR) in conjunction with the Parent-implemented Early Start Denver Model (P-ESDM). A previous report described improved metrics of parental distress (Weitlauf et al. in Pediatrics 145(Supplement 1):S81-S92, 2020). This manuscript examines child outcomes.…
Descriptors: Longitudinal Studies, Randomized Controlled Trials, Metacognition, Stress Management
Zheng, Zhi; Nie, Guangtao; Swanson, Amy; Weitlauf, Amy; Warren, Zachary; Sarkar, Nilanjan – Journal of Autism and Developmental Disorders, 2020
Although there has been growing interest in utilizing robots for intervention in autism spectrum disorder (ASD), there have been very few controlled trials to assess the actual impacts of such systems on social communication vulnerabilities. This study reports a randomized controlled trial to investigate a robot-mediated response to joint…
Descriptors: Randomized Controlled Trials, Robotics, Intervention, Autism
Scheithauer, Mindy; Call, Nathan A.; Lomas Mevers, Joanna; McCracken, Courtney E.; Scahill, Lawrence – Journal of Autism and Developmental Disorders, 2021
Elopement is a common and dangerous concern in autism spectrum disorder (ASD). There is evidence that behavior analytic treatments can successfully treat elopement, but the research is limited due to small samples and treatment components varying across studies. The current study evaluated the feasibility of studying a manualized intervention for…
Descriptors: Randomized Controlled Trials, Intervention, Behavior Problems, Children
Armstrong, Jodie; Girdler, Sonya; Davidson, Emma; Mizen, Joanne; Bear, Natasha; Wray, John; Elliott, Catherine – Journal of Autism and Developmental Disorders, 2021
A single-blind randomised control trial investigated the effectiveness of the Learn, Engage and Play (LEaP) playgroup. Seventy-one children with developmental delay were randomly allocated to an 8-week LEaP playgroup or control group and followed up at 12 and 28 weeks. On the primary outcome measure, LEaP demonstrated significant within group…
Descriptors: Randomized Controlled Trials, Developmental Delays, Children, Play Therapy
Pi, Hong Ji; Kallapiran, Kannan; Munivenkatappa, Shashidhara; Kandasamy, Preeti; Kirubakaran, Richard; Russell, Paul; Eapen, Valsamma – Journal of Autism and Developmental Disorders, 2022
Technology-assisted parent-mediated interventions improve accessibility and are acceptable but not proven to be effective. We conducted a systematic search of 6 databases. We included and analysed results from studies on social and communication outcomes. Sixteen Randomised-Controlled-Trials (RCTs) with 748 participants were included. Most studies…
Descriptors: Intervention, Autism, Pervasive Developmental Disorders, Children
McDaniel, Jena; Brady, Nancy C.; Warren, Steven F. – Journal of Autism and Developmental Disorders, 2022
We conducted a systematic review to identify randomized controlled trials (RCTs) and single case research design (SCRD) studies of children with autism spectrum disorder that evaluate the effectiveness of responsivity intervention techniques for improving prelinguistic and/or language outcomes. Mean effect sizes were moderate and large for RCTs…
Descriptors: Outcomes of Treatment, Response to Intervention, Child Language, Autism Spectrum Disorders
Sini Li; Yijing Yong; Yamin Li; Jianhe Li; Jiao Xie – Journal of Autism and Developmental Disorders, 2024
This review aims to systematically summarize existing evidence to determine the effectiveness of cognitive-based interventions (CBIs) on psychological health and well-being among parents of children with developmental disabilities (DD). Six databases were searched to identify eligible randomized controlled trials (RCTs) from their inception to…
Descriptors: Parents, Children, Developmental Disabilities, Metacognition
Tromans, Samuel; Adams, Clive – Journal of Autism and Developmental Disorders, 2018
We searched the Cochrane Central Register of Controlled Trials to provide an overview of evidence from randomized controlled trials (RCTs) of therapeutic interventions for autism spectrum disorders. From the final survey (529 RCTs), the mean size was 49 participants (standard deviation 50, range 1-479, median 36, mode 40), with a sharp increase in…
Descriptors: Randomized Controlled Trials, Autism, Pervasive Developmental Disorders, Surveys
Hanrahan, R.; Smith, E.; Johnson, H.; Constantin, A.; Brosnan, M. – Journal of Autism and Developmental Disorders, 2020
Social stories is a widely used intervention for children on the autism spectrum, particularly within an educational context. To date, systematic reviews and meta analyses of the research evaluating social stories has produced mixed results, often due to a lack of methodological rigour and variability in the development and delivery of the social…
Descriptors: Pilot Projects, Randomized Controlled Trials, Story Telling, Autism
Vause, Tricia; Jaksic, Heather; Neil, Nicole; Frijters, Jan C.; Jackiewicz, Grazyna; Feldman, Maurice – Journal of Autism and Developmental Disorders, 2020
Children with autism spectrum disorder (ASD) experience obsessions and compulsions similar to those specified in "DSM-5" for obsessive compulsive disorder yet little controlled research exists on treating these behaviours. Thirty-seven children (7-13 years old) were randomly assigned to a 9-week functional behavior-based cognitive…
Descriptors: Cognitive Restructuring, Behavior Modification, Anxiety Disorders, Children
Chez, Michael; Kile, Shawn; Lepage, Christopher; Parise, Carol; Benabides, Bobbie; Hankins, Andrea – Journal of Autism and Developmental Disorders, 2020
Prior studies have demonstrated successful irritability treatment using dopaminergic antagonists in autistic patients. The purpose of this pilot study was to assess the effect of dextromethorphan/quinidine (DM/Q) in autistic adults (18-60 years of age). This was a randomized, blinded, crossover, study of 14 patients randomized to DM/Q or a placebo…
Descriptors: Outcomes of Treatment, Randomized Controlled Trials, Pilot Projects, Drug Therapy
