Comparison of 16 autistic children receiving psychotropic medication with 16 similar nonmedicated children and their parents found that discriminators of the parental decision to medicate or not included: family stress; the child's speaking ability; and irritable, driven, non-goal-directed child behavior. (DB)

Evaluation of the frequency of ear infections, ear tube drainage, and deafness for 51 autistic children (ages 2-18) indicated that autistic children had a greater incidence of ear infections than matched normal peers and lower functioning children had an earlier onset of ear infections than higher functioning autistic peers. (Author)

This study compared data on sleep disturbances of 22 autistic children obtained by questionnaires with data obtained with actigraphy. Questionnaire responses indicated that autistic children had an earlier morning awakening time and multiple and early night arousals; actigraphic monitoring, however, showed their sleep patterns were normal except…

This paper reviews the methodology in articles that have reported structural neuroimaging or neuropsychological data in adolescent patients with schizophrenia. Identification of methodological issues led to the finding that, at present, no conclusions can be made regarding the presence or absence of neuropsychologic dysfunction or structural…

This study reviewed the literature on the clinical features of Asperger Syndrome, a form of autism, looking for evidence that a tendency toward violence is common in individuals with the syndrome. Although many studies were excluded on the basis of inadequate data, findings of remaining studies did not support the speculation that violence is…

Analysis of data from 126 children with autism found macrocephaly (head circumstance microcephaly (head circumference <3rd centile) was found in 15.1%. Microcephaly was significantly associated with the presence of medical disorders. (Author/DB)

This paper reports on a six-month continuation treatment with naltrexone of six children with autism, previously found to be responsive to naltrexone in a four-week trial. Results indicated the moderate hyperactivity-reducing effect of naltrexone was maintained during the six-month continuation treatment but no additional gains in the domains of…

Results of evaluating effects of fenfluramine on 21 maladaptive behaviors in 20 autistic individuals (from 9 to 30 years old) over a 9-month period using a double-blind, cross-over, placebo-controlled design indicated no significant reductions in maladaptive behaviors and the presence of negative side effects. (Author/DB)

This study compared the social problem solving skills of 15 adolescents with Asperger's syndrome with 15 typically developing adolescents. Subjects were presented with videotaped scenarios. The Asperger's group showed deficiencies in recounting pertinent facts, generating possible high-quality problem solutions, and selecting optimal and preferred…

Analysis of diagnostic questionnaires completed by Japanese parents of 141 autistic children below the age of 12 found that the Japanese peak of abnormal social behavior, including autistic symptoms as reported by parents, was from the ages of 3 to 9 years as compared with the U.S. and European peak of 3 to 6 years. (Author/DB)

This study examined behavioral adjustment in 22 siblings of children with autism. Mothers rated these children as having more behavior problems and fewer prosocial behaviors than a normative sample. Analysis of variables revealed that male siblings and children younger than the autistic sibling engaged in fewer prosocial behaviors. Psychological…

The follow-up study of 16 nonretarded autistic children as adults found that, though most were functioning poorly in terms of occupational-social outcome and psychiatric symptoms, four had essentially recovered. Severity of early autistic behavior was a poor predictor of outcome, but neuropsychologic measures of nonverbal problem solving were…

This study provides support for a potential subclinical marker in the executive function domain of siblings (n=18, ages 8-18) of autistic individuals, compared to learning-disabled controls. No group differences in theory-of-mind abilities were found. The need to develop more sensitive measures is discussed. (Author/JDD)

This study assessed depression, anxiety, and relevant cognitions in 46 adults with borderline, mild, or moderate mental retardation. Consistent with research on other groups, self-reports of depression and anxiety were highly correlated and cognitions were strong predictors of negative affect. Hierarchical multiple regression analyses offered…

This study examined Autism Diagnostic Interviews Revised (ADI-R) data for 69 autistic subjects from multiplex (MP) families (with more than one autistic member) and 88 autistic subjects from singleton (SP) families (with only one autistic member). Multivariate analysis revealed no differences between verbal or nonverbal MP and SP groups for ADI-R…