A pilot study was conducted to develop a marijuana knowledge scale and test feasibility of an information literacy-focused intervention targeting college students. First, students recruited from four classes completed an online survey measuring knowledge, attitudes, and intention to use marijuana and the responses (n = 117) were used to create a 19-item knowledge scale. Subsequently, one-hour group intervention was delivered in two of the four classes and volunteers among them completed a post-test (n = 34). The results showed that the intervention increased knowledge and decreased peer approval. Knowledge gain was higher among those with lower initial confidence in their knowledge. No direct effects were found on risk or intention to use.