This article reports on a study conducted to explore the barriers towards accessible quality higher education for students with disabilities (SwDs) in a South African Open Distance and e-Learning (ODeL) institution. The ultimate purpose of this study is to understand and shed light on the challenges that need to be addressed to improve the Unisa practices in a manner that would ensure accessible quality higher education for SwDs. As such, this study which is of a qualitative nature employed a single case study research design wherein nine interviews with lecturers from seven teaching colleges at Unisa are conducted. The findings reveal that, based on the perceptions of lecturers, quality higher education for SwDs at Unisa is hampered by lack of awareness and clear procedures to identify SwDs, inaccessible learning material for SwDs and lack of capacity by lecturers to support SwDs. While it is expected that this study may not culminate in recommendations for practice as a result of limitations posed by its design, it is anticipated that its logical ending points will serve to influence future practice. Nevertheless, it is recommended for future research in South African ODeL to focus on identifying best practices that can be adapted to enhance quality higher education for SwDs in relation to the above-mentioned challenges.