In real-world situations, multidimensional data may appear on large-scale tests or psychological surveys. The purpose of this study was to investigate the effects of the quantity and magnitude of cross-loadings and model specification on item parameter recovery in multidimensional Item Response Theory (MIRT) models, especially when the model was misspecified as a simple structure, ignoring the quantity and magnitude of cross-loading. A simulation study that replicated this scenario was designed to manipulate the variables that could potentially influence the precision of item parameter estimation in the MIRT models. Item parameters were estimated using marginal maximum likelihood, utilizing the expectation-maximization algorithms. A compensatory two-parameter logistic-MIRT model with two dimensions and dichotomous item-responses was used to simulate and calibrate the data for each combination of conditions across 500 replications. The results of this study indicated that ignoring the quantity and magnitude of cross-loading and model specification resulted in inaccurate and biased item discrimination parameter estimates. As the quantity and magnitude of cross-loading increased, the root mean square of error and bias estimates of item discrimination worsened.