In 2014, the Administration for Children and Families (ACF) granted funds to establish Early Head Start-Child Care Partnerships (EHS-CCPs) to expand families' access to high-quality child care. Through these partnerships, Early Head Start grantees have worked with center-based and family child care providers to implement Head Start Program Performance Standards (HSPPS) and provide comprehensive services and resources to meet the needs of low-income families with infants and toddlers in community child care settings. In 2016, the W.K. Kellogg Foundation commissioned Child Trends to engage with six EHS-CCPs that received additional funding from the Foundation to support partnership implementation. From 2016 to 2020, Child Trends carried out activities to learn more about the partnerships, including the challenges and benefits of working in partnerships. This resource first defines childhood adversity, and briefly describes how adversity experienced in childhood does (or does not) affect outcomes later in life. Next, it provides an overview of research on the effects that EHS and Head Start (HS) have on participating children and families who have experienced adversity. It then shifts to discussing adversity that EHS-CCP staff may have experienced and the effects of their experiences on their work with children, using a case study to illustrate approaches for supporting staff.